Energy transfer mechanisms in photobiological reactions. Final report, 1 April 1960--31 March 1979. [Photodynamic processes in selected biomolecules]
This project was concerned primarily with studies of the mechanisms of the sensitized photooxidation of selected biomolecules using a variety of phtosensitizers. Such reactions are often termed photodynamic processes. In particular we have carried out steady-state kinetic studies, flash photolysis and spectral studies, and product formation studies of the sensitized photooxidation of the five susceptible amino acids (cycteine, histidine, methonine, tryptophan, and tyrosine) and their derivatives, as well as purines and pyrimidines. A number of studies were also carried out on the mechanisms of the photodynamic inactivation of enzymes (trypsin, ribonuclease, lysozyme). Mechanism of photosensitization were studied using a variety of sensitizers including flavins, porphyrins, and a number of synthetic dyes (substituted fluoresceins, acridines, thyazines).
- Research Organization:
- Utah Univ., Salt Lake City (USA). Dept. of Biology
- OSTI ID:
- 6471328
- Report Number(s):
- COO-875-180
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
400500 -- Photochemistry
550200 -- Biochemistry
560111* -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACRIDINES
AMINO ACIDS
AROMATICS
AZINES
AZOLES
BIOCHEMICAL REACTION KINETICS
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
CHEMISTRY
CYSTEINE
DECOMPOSITION
DYES
ELEMENTARY PARTICLES
ENZYMES
FLUORESCEIN
GLYCOSYL HYDROLASES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HISTIDINE
HYDROLASES
HYDROXY ACIDS
HYDROXY COMPOUNDS
IMIDAZOLES
IN VITRO
INDOLES
IRRADIATION
ISOALLOXAZINES
KINETICS
LIPOTROPIC FACTORS
LYSOZYME
MASSLESS PARTICLES
METHIONINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PEPTIDE HYDROLASES
PHENOLS
PHOSPHOTRANSFERASES
PHOTOCHEMICAL REACTIONS
PHOTOCHEMISTRY
PHOTOLYSIS
PHOTONS
PHOTOSENSITIVITY
POLYPHENOLS
PORPHYRINS
PURINES
PYRIDINES
PYRIMIDINES
PYRROLES
RADIOSENSITIVITY EFFECTS
REACTION KINETICS
RNA-ASE
SENSITIVITY
STEADY-STATE CONDITIONS
THIOLS
TRANSFERASES
TRYPSIN
TRYPTOPHAN
TYROSINE