Immunodeficiency with thymoma: failure to induce Ig production in immunodeficient lymphocytes cocultured with normal T cells. [X radiation]
Blood mononuclear cells of two individuals having immunodeficiency with thymoma (ID-THY) were cocultured with normal mononuclear cells or treated mononuclear cell fractions in an attempt to correct an imbalance of regulatory cells postulated to be responsible for the failure of pokeweed mitogen-induced Ig synthesis in vitro. Treatment included abrogation of suppressor cell activity by irradiation or incubation with prednisolone in vitro. T cell help was provided by cocultivating lymphocytes of related and unrelated persons, and in some cases autologous treated cells. Ig secretion failed to be induced by any experimental maneuver suggesting that the primary problem in the above ID-THY cells was related to defective or deficient B cells rather than an imbalance of T regulatory cells. Prednisolone treatment in vitro decreased suppressor cell activity in allogeneic cocultures of two ID-THY persons (S1 and S2) but not of an individual (S3) with variable immunodeficiency suggesting heterogeneity of suppressor cells.
- Research Organization:
- Cornell Univ. Medical College, New York
- OSTI ID:
- 6471286
- Journal Information:
- J. Immunol.; (United States), Vol. 122:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
IMMUNOGLOBULINS
BIOSYNTHESIS
LYMPHOCYTES
IMMUNE REACTIONS
NEOPLASMS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
PREDNISOLONE
THYMOCYTES
THYMUS
X RADIATION
ADRENAL HORMONES
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
CORTICOSTEROIDS
DISEASES
ELECTROMAGNETIC RADIATION
GLOBULINS
GLUCOCORTICOIDS
HORMONES
HYDROXY COMPOUNDS
IONIZING RADIATIONS
KETONES
LEUKOCYTES
LYMPHATIC SYSTEM
ORGANIC COMPOUNDS
ORGANS
PREGNANES
PROTEINS
RADIATION EFFECTS
RADIATIONS
SOMATIC CELLS
STEROID HORMONES
STEROIDS
SYNTHESIS
560121* - Radiation Effects on Cells- External Source- (-1987)