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Immunodeficiency with thymoma: failure to induce Ig production in immunodeficient lymphocytes cocultured with normal T cells. [X radiation]

Journal Article · · J. Immunol.; (United States)
OSTI ID:6471286
Blood mononuclear cells of two individuals having immunodeficiency with thymoma (ID-THY) were cocultured with normal mononuclear cells or treated mononuclear cell fractions in an attempt to correct an imbalance of regulatory cells postulated to be responsible for the failure of pokeweed mitogen-induced Ig synthesis in vitro. Treatment included abrogation of suppressor cell activity by irradiation or incubation with prednisolone in vitro. T cell help was provided by cocultivating lymphocytes of related and unrelated persons, and in some cases autologous treated cells. Ig secretion failed to be induced by any experimental maneuver suggesting that the primary problem in the above ID-THY cells was related to defective or deficient B cells rather than an imbalance of T regulatory cells. Prednisolone treatment in vitro decreased suppressor cell activity in allogeneic cocultures of two ID-THY persons (S1 and S2) but not of an individual (S3) with variable immunodeficiency suggesting heterogeneity of suppressor cells.
Research Organization:
Cornell Univ. Medical College, New York
OSTI ID:
6471286
Journal Information:
J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 122:2; ISSN JOIMA
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CELL CULTURES
CONNECTIVE TISSUE CELLS
CORTICOSTEROIDS
DISEASES
ELECTROMAGNETIC RADIATION
GLOBULINS
GLUCOCORTICOIDS
HORMONES
HYDROXY COMPOUNDS
IMMUNE REACTIONS
IMMUNOGLOBULINS
IONIZING RADIATIONS
KETONES
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
PREDNISOLONE
PREGNANES
PROTEINS
RADIATION EFFECTS
RADIATIONS
SOMATIC CELLS
STEROID HORMONES
STEROIDS
SYNTHESIS
THYMOCYTES
THYMUS
X RADIATION