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Temporal analysis of a dose-response relationship: leukemia mortality in atomic bomb survivors

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3576329· OSTI ID:6470735
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A data analysis that incorporates time dependencies is demonstrated for the dose response of leukemia mortality in the atomic bomb survivors. The time dependencies are initially left unspecified and the data on leukemia mortality, up to the end of 1978, are used to infer them. Several findings based on T65 revised doses (T65DR) are obtained. First, it is shown that the fits to the data of time-independent L (linear in ..gamma.. dose)-Q (quadratic in ..gamma.. dose)-L (linear in nuetron dose, L-L, and Q-L dose-response models are significantly improved by using the corresponding time-dependent dose-response models. Second, it is shown that the increased risk of leukemia mortality due to ..gamma.. irradiation decreases in time while the increased risk due to neutron exposure decreases more slowly, if at all, in time. Consequently, relative biological effectiveness (RBE) of neutrons is shown to increase in time and the current definition of RBE as a time-dependent quantity is therefore challenged. It is demonstrated with time-dependent models that the L-L model has a poor fit to the data for the first 7 years of study, but has an adequate fit for the remaining 21 years. In contrast the Q-L model has an adequate fit for the entire follow-up period.

Research Organization:
Oak Ridge Associated Universities, TN
DOE Contract Number:
AC05-76OR00033; AC01-76EV03161
OSTI ID:
6470735
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 99:3; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
A-BOMB SURVIVORS
BARYONS
CARCINOGENESIS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
FERMIONS
FISSION NEUTRONS
GAMMA RADIATION
HADRONS
HEMIC DISEASES
HUMAN POPULATIONS
IONIZING RADIATIONS
LEUKEMIA
LEUKEMOGENESIS
MATHEMATICAL MODELS
MORTALITY
NEOPLASMS
NEUTRONS
NUCLEONS
PATHOGENESIS
POPULATIONS
RADIATIONS
RADIOINDUCTION
RBE
RISK ASSESSMENT
TIME DEPENDENCE