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Title: Lung clearance and disposition of /sup 63/Ni in F344/N rats after intratracheal instillation of nickel sulfate solutions

Abstract

Epidemiology studies have indicated increased incidences of respiratory tract and renal cancer in nickel refinery workers. Since the most likely route of exposure to nickel in the workplace is via the respiratory tract, the objectives of the experiments described here were to determine the retention pattern of Ni in the lungs, identify the target organs for Ni absorbed from the respiratory tract, and determine rates for excretion of Ni. Male and female F344 rats were given 17, 190, or 1800 nmoles Ni (as a nickel sulfate solution) in saline, containing trace amounts of /sup 63/Ni, by intratracheal instillation. Urine and feces were collected, and rats were necropsied at predetermined times up to 96 hr after instillation. At all times, lungs, trachea, larynx, kidney, and urinary bladder contained the highest concentrations of Ni as determined by liquid scintillation spectrometry. Urine was the major route for excretion of Ni, accounting for 50% of the dose after instillation of 17 or 190 nmoles Ni, and 80% of the dose after instillation of 1800 nmoles Ni. The half-time for urinary excretion of Ni increased from 4.6 hr at the highest dose to 23 hr at the lowest dose used. Fecal excretion accounted for 30%more » (17- and 190-nmole doses) or 13% (1800 nmoles) of the initial dose. Of the Ni remaining in the body at the end of 96 hr, over 50% was in the lungs. The long-term half-time for clearance of Ni from the lungs ranged from 21 hr at the highest dose to 36 hr at the lowest dose instilled. As the amount of instilled Ni decreased, the fraction of the instilled Ni associated with the long-term clearance component increased (from 24% at the highest dose to 40% at the lowest dose). Results suggest that, over the range of doses studied, both pulmonary clearance of Ni and routes for excretion of Ni were dependent on the instilled dose.« less

Authors:
; ;
Publication Date:
Research Org.:
Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM
OSTI Identifier:
6470618
Resource Type:
Journal Article
Journal Name:
Environ. Res.; (United States)
Additional Journal Information:
Journal Volume: 1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; NICKEL; METABOLISM; TOXICITY; BIOLOGICAL HALF-LIFE; CLEARANCE; FECES; NICKEL 63; RATS; TISSUE DISTRIBUTION; TRACER TECHNIQUES; URINE; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY FLUIDS; DISTRIBUTION; ELEMENTS; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; MATERIALS; METALS; NICKEL ISOTOPES; NUCLEI; RADIOISOTOPES; RODENTS; TRANSITION ELEMENTS; VERTEBRATES; WASTES; YEARS LIVING RADIOISOTOPES; 560300* - Chemicals Metabolism & Toxicology; 550501 - Metabolism- Tracer Techniques

Citation Formats

Medinsky, M A, Benson, J M, and Hobbs, C H. Lung clearance and disposition of /sup 63/Ni in F344/N rats after intratracheal instillation of nickel sulfate solutions. United States: N. p., 1987. Web.
Medinsky, M A, Benson, J M, & Hobbs, C H. Lung clearance and disposition of /sup 63/Ni in F344/N rats after intratracheal instillation of nickel sulfate solutions. United States.
Medinsky, M A, Benson, J M, and Hobbs, C H. Mon . "Lung clearance and disposition of /sup 63/Ni in F344/N rats after intratracheal instillation of nickel sulfate solutions". United States.
@article{osti_6470618,
title = {Lung clearance and disposition of /sup 63/Ni in F344/N rats after intratracheal instillation of nickel sulfate solutions},
author = {Medinsky, M A and Benson, J M and Hobbs, C H},
abstractNote = {Epidemiology studies have indicated increased incidences of respiratory tract and renal cancer in nickel refinery workers. Since the most likely route of exposure to nickel in the workplace is via the respiratory tract, the objectives of the experiments described here were to determine the retention pattern of Ni in the lungs, identify the target organs for Ni absorbed from the respiratory tract, and determine rates for excretion of Ni. Male and female F344 rats were given 17, 190, or 1800 nmoles Ni (as a nickel sulfate solution) in saline, containing trace amounts of /sup 63/Ni, by intratracheal instillation. Urine and feces were collected, and rats were necropsied at predetermined times up to 96 hr after instillation. At all times, lungs, trachea, larynx, kidney, and urinary bladder contained the highest concentrations of Ni as determined by liquid scintillation spectrometry. Urine was the major route for excretion of Ni, accounting for 50% of the dose after instillation of 17 or 190 nmoles Ni, and 80% of the dose after instillation of 1800 nmoles Ni. The half-time for urinary excretion of Ni increased from 4.6 hr at the highest dose to 23 hr at the lowest dose used. Fecal excretion accounted for 30% (17- and 190-nmole doses) or 13% (1800 nmoles) of the initial dose. Of the Ni remaining in the body at the end of 96 hr, over 50% was in the lungs. The long-term half-time for clearance of Ni from the lungs ranged from 21 hr at the highest dose to 36 hr at the lowest dose instilled. As the amount of instilled Ni decreased, the fraction of the instilled Ni associated with the long-term clearance component increased (from 24% at the highest dose to 40% at the lowest dose). Results suggest that, over the range of doses studied, both pulmonary clearance of Ni and routes for excretion of Ni were dependent on the instilled dose.},
doi = {},
url = {https://www.osti.gov/biblio/6470618}, journal = {Environ. Res.; (United States)},
number = ,
volume = 1,
place = {United States},
year = {1987},
month = {6}
}