DNA sequences, recombinant DNA molecules and processes for producing the A and B subunits of cholera toxin and preparations containing so-obtained subunit or subunits

Patent · Tue May 19 00:00:00 EDT 1987

OSTI ID:6470592

Harford, N; De Wilde, M

A recombinant DNA molecule is described comprising at least a portion coding for subunits A and B of cholera toxin, or a fragment or derivative of the portion wherein the fragment or derivative codes for a polypeptide have an activity which can induce an immune response to subunit A; can induce an immune response to subunit A and cause epithelial cell penetration and the enzymatic effect leading to net loss of fluid into the gut lumen; can bind to the membrane receptor for the B subunit of cholera toxin; can induce an immune response to subunit B; can induce an immune response to subunit B and bind to the membrane receptor; or has a combination of the activities.

• Assignee: SmithKline-RIT
• Patent Number(s): US 4666837
• OSTI ID: 6470592
• Resource Relation: Patent File Date: Filed date 24 May 1982
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CHOLERA
DNA SEQUENCING
RECOMBINANT DNA
ENDOTOXINS
ENZYME ACTIVITY
EPITHELIUM
IMMUNE REACTIONS
MEMBRANES
POLYPEPTIDES
RECEPTORS
TOXINS
ANIMAL TISSUES
ANTIGENS
BACTERIAL DISEASES
BODY
DISEASES
DNA
INFECTIOUS DISEASES
MATERIALS
MEMBRANE PROTEINS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PEPTIDES
PROTEINS
STRUCTURAL CHEMICAL ANALYSIS
TISSUES
TOXIC MATERIALS
550200* - Biochemistry