DNA sequences, recombinant DNA molecules and processes for producing the A and B subunits of cholera toxin and preparations containing so-obtained subunit or subunits
Patent
·
OSTI ID:6470592
A recombinant DNA molecule is described comprising at least a portion coding for subunits A and B of cholera toxin, or a fragment or derivative of the portion wherein the fragment or derivative codes for a polypeptide have an activity which can induce an immune response to subunit A; can induce an immune response to subunit A and cause epithelial cell penetration and the enzymatic effect leading to net loss of fluid into the gut lumen; can bind to the membrane receptor for the B subunit of cholera toxin; can induce an immune response to subunit B; can induce an immune response to subunit B and bind to the membrane receptor; or has a combination of the activities.
- Assignee:
- SmithKline-RIT
- Patent Number(s):
- US 4666837
- OSTI ID:
- 6470592
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
ANTIGENS
BACTERIAL DISEASES
BODY
CHOLERA
DISEASES
DNA
DNA SEQUENCING
ENDOTOXINS
ENZYME ACTIVITY
EPITHELIUM
IMMUNE REACTIONS
INFECTIOUS DISEASES
MATERIALS
MEMBRANE PROTEINS
MEMBRANES
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PEPTIDES
POLYPEPTIDES
PROTEINS
RECEPTORS
RECOMBINANT DNA
STRUCTURAL CHEMICAL ANALYSIS
TISSUES
TOXIC MATERIALS
TOXINS
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
ANTIGENS
BACTERIAL DISEASES
BODY
CHOLERA
DISEASES
DNA
DNA SEQUENCING
ENDOTOXINS
ENZYME ACTIVITY
EPITHELIUM
IMMUNE REACTIONS
INFECTIOUS DISEASES
MATERIALS
MEMBRANE PROTEINS
MEMBRANES
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PEPTIDES
POLYPEPTIDES
PROTEINS
RECEPTORS
RECOMBINANT DNA
STRUCTURAL CHEMICAL ANALYSIS
TISSUES
TOXIC MATERIALS
TOXINS