Expression and rearrangement of the ROS1 gene in human glioblastoma cells
Journal Article
·
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
The human ROS1 gene, which possibly encodes a growth factor receptor, was found to be expressed in human tumor cell lines. In a survey of 45 different human cell lines, the authors found ROS1 to be expressed in glioblastoma-derived cell lines at high levels and not to be expressed at all, or expressed at very low levels, in the remaining cell lines. The ROS1 gene was present in normal copy numbers in all cell lines that expressed the gene. However, in one particular glioblastoma line, they detected a potentially activating mutation at the ROS1 locus.
- Research Organization:
- Cold Spring Harbor Lab., NY (USA)
- OSTI ID:
- 6469853
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Vol. 84:24
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
GLIOMAS
GENETICS
MESSENGER-RNA
AUTORADIOGRAPHY
ONCOGENES
MOLECULAR BIOLOGY
HYBRIDIZATION
MAN
MUTATIONS
PHOSPHORUS 32
TRANSCRIPTION
TUMOR CELLS
TYROSINASE
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGY
DAYS LIVING RADIOISOTOPES
DISEASES
ENZYMES
GENES
HYDROXYLASES
ISOTOPES
LIGHT NUCLEI
MAMMALS
NEOPLASMS
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
OXIDOREDUCTASES
PHOSPHORUS ISOTOPES
PRIMATES
RADIOISOTOPES
RNA
VERTEBRATES
550201* - Biochemistry- Tracer Techniques
GLIOMAS
GENETICS
MESSENGER-RNA
AUTORADIOGRAPHY
ONCOGENES
MOLECULAR BIOLOGY
HYBRIDIZATION
MAN
MUTATIONS
PHOSPHORUS 32
TRANSCRIPTION
TUMOR CELLS
TYROSINASE
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGY
DAYS LIVING RADIOISOTOPES
DISEASES
ENZYMES
GENES
HYDROXYLASES
ISOTOPES
LIGHT NUCLEI
MAMMALS
NEOPLASMS
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
OXIDOREDUCTASES
PHOSPHORUS ISOTOPES
PRIMATES
RADIOISOTOPES
RNA
VERTEBRATES
550201* - Biochemistry- Tracer Techniques