Comparative biochemical characteristics of isotope-labeled compounds and their unlabeled analog (survey)

Journal Article · Mon Dec 01 04:00:00 EST 1986 · Pharmaceut. Chem. J.; (United States)

DOI:https://doi.org/10.1007/BF00766894· OSTI ID:6469785

Fateev, V A; Titov, N S

One of the most widespread methodological approaches to the study of biochemical processes is the use of endogenous and exogenous compounds, into the molecules of which stable or radioactive isotopes have been introduced. The authors present a survey that generalizes the literature data showing the biochemical properties of labeled and unlabeled preparations from a comparative standpoint. The influence of stable isotopes is discussed, in particular the introduction of deuterium as a label into the structure of drug molecules which may substantially change their biotransformation. The influence of radioactive isotopes is examined, and in a study of the tissue toxicity of /sup 3/H-, /sup 14/C-, and /sup 35/S-labeled proline, serine, lysine, and methionine, it was revealed that they caused a pronounced lesion of the lungs of rat embryos in culture, among other effects.

• Research Organization: Yaroslavl Medical Institute (USSR)
• OSTI ID: 6469785
• Journal Information: Pharmaceut. Chem. J.; (United States), Journal Name: Pharmaceut. Chem. J.; (United States) Vol. 20:2; ISSN PCJOA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400202 -- Isotope Effects
Isotope Exchange
& Isotope Separation
550201* -- Biochemistry-- Tracer Techniques
550501 -- Metabolism-- Tracer Techniques
560160 -- Radionuclide Effects
Kinetics
& Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BINDING ENERGY
BIOCHEMICAL REACTION KINETICS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARBON 14 COMPOUNDS
CHEMICAL PROPERTIES
CHEMICAL REACTIONS
CHEMISTRY
CLEARANCE
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DEUTERATION
DEUTERIUM COMPOUNDS
DOCUMENT TYPES
DRUGS
ENERGY
EVEN-ODD NUCLEI
HYDROGEN COMPOUNDS
ISOTOPE EFFECTS
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
METABOLISM
NUCLEI
RADIATION EFFECTS
RADIOISOTOPES
RADIONUCLIDE KINETICS
REACTION KINETICS
REVIEWS
SULFUR 35
SULFUR ISOTOPES
TOXICITY
TRITIUM COMPOUNDS