Detection of abnormalities in febrile AIDS patients with In-111-labeled leukocyte and Ga-67 scintigraphy

Journal Article · Wed Mar 01 00:00:00 EST 1989 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.170.3.2783783· OSTI ID:6467739

Fineman, D S; Palestro, C J; Kim, C K; Needle, L B; Vallabhajosula, S; Solomon, R W; Goldsmith, S J

Thirty-six patients with acquired immunodeficiency syndrome (AIDS), who were febrile but without localizing signs, underwent indium-111 leukocyte scintigraphy 24 hours after injection of labeled white blood cells (WBCs) and were restudied 48 hours after injection of gallium-67 citrate. Fifty-six abnormalities were identified as possible sources of the fever; 27 were confirmed with biopsy. Of these 27, 15 were identified only on In-111 WBC scans (including colitis, sinusitis, and focal bacterial pneumonia); six, only on Ga-67 scans (predominantly Pneumocystis carinii pneumonia and lymphadenopathy); and six, on both studies (predominantly pulmonary lesions). In-111 WBC scanning revealed 21 of 27 abnormalities (78%) and gallium scanning, 12 of 27 (44%). If only one scintigraphic study has been performed, particularly with Ga-67, a significant number of lesions would not have been detected. The authors believe radionuclide evaluation of the febrile AIDS patient without localizing signs should begin with In-111 WBC scintigraphy. Gallium scanning may be used depending on results of In-111 WBC scans or if there is a high index of suspicion for P carinii pneumonia.

• Research Organization: Mount Sinai Medical Center, New York, NY (USA)
• OSTI ID: 6467739
• Journal Information: Radiology; (United States), Vol. 170
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
DIGESTIVE SYSTEM DISEASES
DIAGNOSIS
LEUKOCYTES
SCINTISCANNING
PNEUMONIA
RADIOPHARMACEUTICALS
COMPARATIVE EVALUATIONS
AIDS
CITRATES
FEVER
GALLIUM 67
INDIUM 111
PATIENTS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACID SALTS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM ISOTOPES
HEMIC DISEASES
IMMUNE SYSTEM DISEASES
INDIUM ISOTOPES
INFECTIOUS DISEASES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM DISEASES
SYMPTOMS
VIRAL DISEASES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550901 - Pathology- Tracer Techniques