Patterns of colonic transit in chronic idiopathic constipation
Rectosigmoid motility, anal manometry, and radiopaque marker studies have suggested the presence of several patterns of altered colonic transit in patients with chronic idiopathic constipation. Colonic transit scintigraphy was used to evaluate 23 constipated patients. After oral passage of a tube to the cecum, 50 microCi of /sup 111/In-diethylenetriaminepentaaceticacid (/sup 111/In-DTPA) were instilled, and abdominal images were obtained for 48 h with a gamma camera. The 95% confidence limit for the geometric center in normals at 24 h was used as a criterion to differentiate patients with colonic inertia from those with functional rectosigmoid obstruction. In patients with functional rectosigmoid obstruction, colonic transit was essentially normal. In colonic inertia, transit was delayed in the cecum and ascending colon, hepatic flexure, and transverse colon. These two distinct patterns of colonic transit may have different pathogenetic and therapeutic implications.
- Research Organization:
- Temple Univ. School of Medicine, Philadelphia, PA (USA)
- OSTI ID:
- 6467648
- Journal Information:
- Am. J. Gastroenterol.; (United States), Vol. 84:2
- Country of Publication:
- United States
- Language:
- English
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DIGESTIVE SYSTEM DISEASES
DIAGNOSIS
LARGE INTESTINE
SCINTISCANNING
ABDOMEN
CONSTIPATION
DTPA
GAMMA CAMERAS
INDIUM 111
PATIENTS
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BODY
BODY AREAS
CAMERAS
CARBOXYLIC ACIDS
CHELATING AGENTS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GASTROINTESTINAL TRACT
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
INTESTINES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
SYMPTOMS
550601* - Medicine- Unsealed Radionuclides in Diagnostics