Minimal pathologic changes of the lung and asbestos exposure

Journal Article · Tue Jan 31 23:00:00 EST 1989 · Hum. Pathol.; (United States)

DOI:https://doi.org/10.1016/0046-8177(89)90172-X· OSTI ID:6464969

Bellis, D; Andrion, A; Delsedime, L; Mollo, F

A group of 199 autopsy subjects was investigated for minimal pathologic pulmonary changes possibly resulting from asbestos exposure. According to the standards proposed by the Pneumoconiosis Committee of the College of American Pathologists, features consistent with asbestosis grade 1 (AG1) include findings of bilateral pleural plaques, high concentrations of asbestos bodies (ABs) in digested lung tissue, and a history of occupational risk. Similar changes without evidence of ABs on histologic section and referred to as small airway lesions (SALs) present a less well-correlated association. In this study, SALs showed significant differences when compared with the features observed in subjects without possible asbestos-related pulmonary fibrotic changes. Minimal bronchioloalveolar fibrotic changes with concomitant presence of ABs can be considered a mild pneumoconiotic lesion (AG1), and SALs may be regarded as an additional indicator of asbestos exposure.

• Research Organization: Univ. of Turin (Italy)
• OSTI ID: 6464969
• Journal Information: Hum. Pathol.; (United States), Journal Name: Hum. Pathol.; (United States) Vol. 20:2; ISSN HPCQA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ASBESTOS
AUTOPSY
BODY
DIAGNOSTIC TECHNIQUES
LUNGS
MAMMALS
MAN
MEMBRANES
OCCUPATIONAL EXPOSURE
ORGANS
PATHOLOGICAL CHANGES
PLEURA
PRIMATES
RESPIRATORY SYSTEM
SEROUS MEMBRANES
TOXICITY
VERTEBRATES