Foetal distribution of inhaled mercury vapor in normal and acatalasaemic mice

Journal Article · Wed Jan 01 04:00:00 EST 1986 · Physiol. Chem. Phys. Med. NMR; (United States)

OSTI ID:6464678

Ogata, M; Meguro, T

Levels of mercury distribution in placenta, amniotic sac and foetus and those in brain and liver of maternal acatasaemic mice were higher than those of normal, respectively. The levels of mercury distribution in the blood and lungs of maternal acatalasaemic mice exposed to metallic mercury vapor were also lower than those of normal. Mercury concentrations in placenta and foetus of acatalasaemic mice following exposure to metallic mercury vapor were higher than those of normal. Maternal acatalasaemic mice had decreased levels of mercury in the blood than those of normal mice. Thus, the placenta/blood or foetus/blood ratio of mercury concentration in acatalasaemic mice was significantly higher than that in normal mice. Similarly the brain/blood or liver/blood ratio of maternal acatalasaemic mice was higher than that of normal mice. These results suggest that metallic mercury in the blood readily passed through the blood-brain, blood-foetus barriers. In contrast to the results on exposures of mice to metallic mercury, the foetus/maternal blood ratio of mercuric concentration in the acatalasaemic mice following injection of mercuric chloride was similar to that in the normal mice. Moreover, the foetus/maternal blood ratio of mercury concentration in acatalasaemic or normal mice injected with mercuric chloride was lower than those in acatalasaemic or normal mice exposed to metallic mercury.

• Research Organization: Okayama Univ. Medical School, Japan
• OSTI ID: 6464678
• Journal Information: Physiol. Chem. Phys. Med. NMR; (United States), Journal Name: Physiol. Chem. Phys. Med. NMR; (United States) Vol. 3; ISSN PCPNE
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD-BRAIN BARRIER
BODY
BODY FLUIDS
BRAIN
CATALASE
CENTRAL NERVOUS SYSTEM
COLLOIDS
DIGESTIVE SYSTEM
DISPERSIONS
DISTRIBUTION
ELEMENTS
ENZYMES
FETAL MEMBRANES
FETUSES
FLUIDS
GASES
GLANDS
INHALATION
INTAKE
LIVER
LUNGS
MAMMALS
MATERIALS
MEMBRANE TRANSPORT
MEMBRANES
MERCURY
METABOLISM
METALS
MICE
NERVOUS SYSTEM
ORGANS
OXIDOREDUCTASES
PEROXIDASES
PLACENTA
PREGNANCY
RESPIRATORY SYSTEM
RODENTS
SOLS
TISSUE DISTRIBUTION
VAPORS
VERTEBRATES