Synthesis and psychotropic activity of functionally substituted diaziridines and bisdiaziridines
Journal Article
·
· Pharmaceut. Chem. J.; (United States)
OSTI ID:6464118
The authors examine the psychotropic activity of diaziridines which differ considerable in their structures and the C- and N-substituents. Diaziridines are monoamine oxidase inhibitors in the brain and, thus, are potential antidepressants. The acute toxicities and some pharmacological effects of diaziridines are shown. Mice were used in the experiments. The bisdiaziridines obtained differ in their /sup 1/H and /sup 13/C NMR spectra. The effect is presented of functionally substituted diaziridines on the effects of reserpine, 5-hydroxytryptophan, tryptamine, corazole, and apomorphine hypothermia.
- Research Organization:
- Institute of Chemical Physics, Moscow (USSR)
- OSTI ID:
- 6464118
- Journal Information:
- Pharmaceut. Chem. J.; (United States), Journal Name: Pharmaceut. Chem. J.; (United States) Vol. 20:6; ISSN PCJOA
- Country of Publication:
- United States
- Language:
- English
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OSTI ID:5733424
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· Bull. Acad. Sci. USSR, Div. Chem. Sci. (Engl. Transl.); (United States)
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Tue Dec 31 23:00:00 EST 1985
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OSTI ID:5962051
Related Subjects
550500* -- Metabolism
560300 -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
640302 -- Atomic
Molecular & Chemical Physics-- Atomic & Molecular Properties & Theory
74 ATOMIC AND MOLECULAR PHYSICS
ANIMALS
ANTIDEPRESSANTS
AZINES
BIOLOGICAL EFFECTS
CARBON 13
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM AGENTS
CHEMICAL SHIFT
COUPLING
COUPLING CONSTANTS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
EVEN-ODD NUCLEI
HETEROCYCLIC COMPOUNDS
HYDROGEN 1
HYDROGEN ISOTOPES
INTERMEDIATE COUPLING
ISOTOPES
J-J COUPLING
LIGHT NUCLEI
MAMMALS
MATERIALS TESTING
MICE
NMR SPECTRA
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHARMACOLOGY
PSYCHOTROPIC DRUGS
PYRIMIDINES
RODENTS
SPECTRA
STABLE ISOTOPES
SYNTHESIS
TESTING
TOXICITY
VERTEBRATES
560300 -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
640302 -- Atomic
Molecular & Chemical Physics-- Atomic & Molecular Properties & Theory
74 ATOMIC AND MOLECULAR PHYSICS
ANIMALS
ANTIDEPRESSANTS
AZINES
BIOLOGICAL EFFECTS
CARBON 13
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM AGENTS
CHEMICAL SHIFT
COUPLING
COUPLING CONSTANTS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
EVEN-ODD NUCLEI
HETEROCYCLIC COMPOUNDS
HYDROGEN 1
HYDROGEN ISOTOPES
INTERMEDIATE COUPLING
ISOTOPES
J-J COUPLING
LIGHT NUCLEI
MAMMALS
MATERIALS TESTING
MICE
NMR SPECTRA
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHARMACOLOGY
PSYCHOTROPIC DRUGS
PYRIMIDINES
RODENTS
SPECTRA
STABLE ISOTOPES
SYNTHESIS
TESTING
TOXICITY
VERTEBRATES