Palliation of hepatic metastases: results of the radiation therapy oncology group pilot study. [X-ray]

Journal Article · Fri May 01 04:00:00 EDT 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(81)90370-9· OSTI ID:6454294

Borgelt, B B ^[1]; Gelber, R; Brady, L W; Griffin, T; Hendrickson, F R

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1. Thomas Jefferson Univ., Hospital, Philadelphia, PA

From May, 1976, to July, 1978, 20 Radiation Therapy Oncology Group (RTOG) institutions participated in a prospective, uncontrolled, non-randomized pilot study designed to gain information regarding the feasibility of hepatic irradiation for the treatment of symptomatic liver metastases. One hundred-three of 109 patients who entered were included in the present analysis. Eligible patients included those with hepatic metastases from solid, non-hematologic tumors documented by liver scan. Patients with solitary liver metastases received either 3040 rad/19 fractions or 3000 rad/15 fractions followed by an optional 2000 rad/10 fractions boost to residual disease. Nausea and/or vomiting was induced or aggravated in 16%. There were no documented cases of radiation-induced hepatitis, nephritis or pneumonitis. Improvement of liver function chemistries occurred in 40% and palpable liver mass was reduced in 49%. The results of this study indicate that rapid courses of whole liver irradiation are well-tolerated with good therapeutic benefit in patients with symptomatic liver metastases.

• OSTI ID: 6454294
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 7:5; ISSN IOBPD
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
ESOPHAGUS
FRACTIONATED IRRADIATION
GLANDS
HARD X RADIATION
IONIZING RADIATIONS
IRRADIATION
LIVER
MEDICINE
METASTASES
NAUSEA
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SKIN
SYMPTOMS
THERAPY
VOMITING
X RADIATION