Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Imaging dopamine receptors in the human brain by position tomography

Journal Article · · Science (Washington, D.C.); (United States)
; ; ; ; ; ; ; ; ;
Neurotransmitter receptors may be involved in a number of neuropsychiatric disease states. The ligand 3-N-(/sup 11/C)methylspiperone, which preferentially binds to dopamine receptors in vivo, was used to image the receptors by positron emission tomography scanning in baboons and in humans. This technique holds promise for noninvasive clinical studies of dopamine receptors in humans.
Research Organization:
Johns Hopkins Medical Institutions, Baltimore, MD
OSTI ID:
6450633
Journal Information:
Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 221; ISSN SCIEA
Country of Publication:
United States
Language:
English

Similar Records

Assessment of dopamine receptor densities in the human brain with carbon-11-labeled N-methylspiperone
Journal Article · Sat Dec 31 23:00:00 EST 1983 · Ann. Neurol.; (United States) · OSTI ID:6539378
Substituted benzamides as ligands for visualization of dopamine receptor binding in the human brain by positron emission tomography
Journal Article · Sat Jun 01 00:00:00 EDT 1985 · Proc. Natl. Acad. Sci. U.S.A.; (United States) · OSTI ID:6289618
The effects of age on dopamine receptors measured by positron tomography in the living human brain
Conference · Sat Dec 31 23:00:00 EST 1983 · J. Nucl. Med.; (United States) · OSTI ID:6930003

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
ANIMALS
APES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBON 11
CARBON ISOTOPES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CHEMICAL PROPERTIES
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DOPAMINE
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HYDROXY COMPOUNDS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MAN
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NEUROREGULATORS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
POSITRON COMPUTED TOMOGRAPHY
PRIMATES
RADIOISOTOPES
RADIOPHARMACEUTICALS
RECEPTORS
SYMPATHOMIMETICS
TOMOGRAPHY
VERTEBRATES