Metabolism of T-2 toxin in rats and rabbits: effects of dose, route, and time
Male, Sprague-Dawley rats and male New Zealand White rabbits were administered tritium-labeled T-2 toxin at 0.15 mg/kg and 0.60 mg/kg of body weight by i.v., oral and dermal routes of administration. The excretion of total radioactivity was determined for six days and the metabolic profiles were determined using HPLC for days 1, 2 and 3. The excretion of radioactivity in the excreta of both species was rapid and nearly complete after 6 days (>95%) in i.v. and orally dosed animals, but only 70 to 80 percent of the administered radioactivity was excreted in dermally dosed rats and rabbits. The major metabolites in the excreta of rats and rabbits were 3'OH HT-2, HT-2, T-2 tetraol, deepoxy T-2 tetraol and several unknowns. In urine and fecal extracts from rats, these metabolites accounted for 59 and 25% of the extracted radioactivity, respectively. An unknown metabolite, tentatively identified as deepoxy 3'OH HT-2 accounted for another 47% of the extracted radioactivity in fecal extracts from rats. In urine and fecal extracts from rabbits, these major metabolites accounted for 71 and 60% of the extracted radioactivity, respectively. An unknown metabolite, tentatively identified as deepoxy 3'OH HT-2 accounted for an additional 26% of the extracted radioactivity in fecal extracts.
- Research Organization:
- Illinois Univ., Urbana (USA)
- OSTI ID:
- 6450004
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIGENS
BIOLOGICAL VARIABILITY
CHROMATOGRAPHY
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIQUID COLUMN CHROMATOGRAPHY
MAMMALS
MATERIALS
METABOLISM
METABOLITES
RABBITS
RATS
RODENTS
SEPARATION PROCESSES
TOXIC MATERIALS
TOXINS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES