Molecular studies of trisomy 18
Journal Article
·
· American Journal of Human Genetics; (United States)
OSTI ID:6449659
- Salisbury District Hospital (United Kingdom)
- Churchill Hospital, Oxford (United Kingdom)
- John Radcliffe Maternity Hospital, Oxford (United Kingdom)
The authors have determined the parental origin of 50 cases of trisomy 18. In 48 cases the additional chromosome was maternal in origin, and in 2 cases it was paternal in origin. Seven cases, including both those with an additional paternal chromosome, appeared to be the result of a postzygotic error. In contrast to the situation in nondisjunction involving chromosomes 21 and X, there was no evidence for nullochiasmate nondisjunction. 44 refs., 1 fig., 2 tabs.
- OSTI ID:
- 6449659
- Journal Information:
- American Journal of Human Genetics; (United States), Journal Name: American Journal of Human Genetics; (United States) Vol. 52:6; ISSN AJHGAG; ISSN 0002-9297
- Country of Publication:
- United States
- Language:
- English
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