Renal excretion of rubidium and potassium: an electron microprobe and clearance study

Journal Article · Sat Oct 01 04:00:00 EDT 1988 · Kidney Int.; (United States)

DOI:https://doi.org/10.1038/ki.1988.202· OSTI ID:6444922

Beck, F X; Doerge, A G; Giebisch, G; Thurau, K

A combination of clearance and electron microprobe studies was carried out to investigate renal rubidium excretion and rubidium distribution between plasma and individual tubule cells. Saline-infused animals were compared with potassium-loaded rats and another group in which rubidium was given in such amounts that the sum of plasma rubidium plus potassium equalled the potassium concentration in the potassium-loaded rats. The renal clearance of rubidium was uniformly less than that of potassium. Nevertheless, rubidium stimulated fractional potassium excretion above the levels observed in both saline- and potassium-loaded animals. When compared with their plasma concentrations, rubidium was concentrated in all tubule cell types more than potassium, and this is most likely due to restriction of passive diffusion of rubidium from cells to extracellular fluid. In addition, heterogeneity of intercalated cell ion composition was observed: one cell group had high chloride and potassium, but low rubidium contents, whereas the other was characterized by low chloride and potassium, but high rubidium contents.

• Research Organization: Univ. of Munich (Germany, F.R.)
• OSTI ID: 6444922
• Journal Information: Kidney Int.; (United States), Journal Name: Kidney Int.; (United States) Vol. 34:4; ISSN KDYIA
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALI METALS
ANIMALS
BODY
CHEMICAL ANALYSIS
CLEARANCE
DISTRIBUTION
ELECTRON MICROPROBE ANALYSIS
ELEMENTS
EXCRETION
KIDNEYS
MAMMALS
METABOLISM
METALS
MICROANALYSIS
ORGANS
POTASSIUM
RATS
RENAL CLEARANCE
RODENTS
RUBIDIUM
TISSUE DISTRIBUTION
VERTEBRATES