Blood-ocular and blood-brain barrier function in streptozocin-induced diabetes in rats

Journal Article · Sat Sep 01 00:00:00 EDT 1984 · Arch. Ophthalmol. (Chicago); (United States)

DOI:https://doi.org/10.1001/archopht.1984.01040031108035· OSTI ID:6444329

Maeepea, O; Karlsson, C; Alm, A

Edetic acid labeled with chromium 51 was injected intravenously in normal rats and in rats with streptozocin-induced diabetes. One hour after the injection the animals were killed and the concentrations of edetic acid 51Cr in vitreous body, retina, and brain were determined. No significant difference was observed between the two groups for either tissue. In a second series, a mixture of tritiated 1-glucose and aminohippuric acid tagged with carbon 14 was injected instead of edetic acid. A substantial accumulation of aminohippuric acid 14C compared with tritiated 1-glucose was observed in the vitreous body and the brain of diabetic rats in comparison with the control group. It is concluded that untreated streptozocin-induced diabetes in rats for one to two weeks will not cause a generalized increase in the permeability of the blood-ocular or the blood-brain barriers, but organic acids may accumulate in the vitreous body as well as in the brain as a consequence of reduced outward transport through these barriers.

• Research Organization: Department of Ophthalmology, University Hospital, Uppsala, Sweden
• OSTI ID: 6444329
• Journal Information: Arch. Ophthalmol. (Chicago); (United States), Journal Name: Arch. Ophthalmol. (Chicago); (United States) Vol. 102:9; ISSN AROPA
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MODELS
BLOOD-BRAIN BARRIER
BODY
BODY AREAS
BRAIN
CARBOHYDRATES
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHROMIUM 51
CHROMIUM ISOTOPES
DIABETES MELLITUS
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE DISEASES
EVEN-ODD NUCLEI
EYES
FACE
GLUCOSE
HEAD
HEXOSES
HIPPURIC ACID
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
METABOLIC DISEASES
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PERMEABILITY
RADIOISOTOPES
RATS
RODENTS
SACCHARIDES
SENSE ORGANS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES