Clinical studies on the radioimmunodetection of tumors containing alpha-fetoprotein

Journal Article · Thu May 15 00:00:00 EDT 1980 · Cancer; (United States)

DOI:https://doi.org/10.1002/1097-0142(19800515)45:10<2500::AID-CNCR2820451006>3.0.CO;2-J· OSTI ID:6443651

Goldenberg, D M; Kim, E E; Deland, F; Spremulli, E; Nelson, M O; Gockerman, J P; Primus, F J; Corgan, R L; Alpert, E

This study reports the use of radiolabeled antibodies to alpha-fetoprotein for the detection and localization of hepatocellular and germ cell carcinomas. Twelve patients with histories of histologically-confirmed neoplasia received a total dose between 1.0 and 4.4 mCi of /sup 131/I-labeled goat IgG prepared against human alpha-fetoprotein. Total-body photoscans were taken with a gamma scintillation camera at various intervals after injection of the radioactive antibody. Computer subtraction of radioactive technetium background images from the antibody /sup 131/I scans permitted the visualization of all tumor sites known to be present in 4 patients with either primary hepatocellular cancer or metastatic germ cell carcinoma of the testis. Among 8 patients with diverse neoplasms not believed to contain alpha-fetoprotein, 5 of 19 tumor sites showed radioactive antibody accretion, although significantly less than in the patients with liver or testicular cancer. This investigation indicates that alpha-fetoprotein-containing tumors can be detected and localized in vivo by the method of radioimmunodetection.

• Research Organization: Univ. of Kentucky, Lexington
• OSTI ID: 6443651
• Journal Information: Cancer; (United States), Journal Name: Cancer; (United States) Vol. 45:10; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
CARCINOMAS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DUAL-ISOTOPE SUBTRACTION TECHNIQUE
ELEMENTS
GLANDS
GLOBULINS
GONADS
IMMUNOGLOBULINS
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIVER
MALE GENITALS
METALS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOISOTOPE SCANNING
RADIOISOTOPES
REFRACTORY METALS
SCINTISCANNING
TECHNETIUM
TESTES
TRACER TECHNIQUES
TRANSITION ELEMENTS