Acetazolamide challenge for three-dimensional time-of-flight MR angiography of the brain

Journal Article · Thu Mar 31 23:00:00 EST 1994 · AJNR. American Journal of Neuroradiology; (United States)

OSTI ID:6442822

Mandai, Kenji; Sueyoshi, Kenji; Fukunaga, Ryuzo; Nukada, Masaru; Ohtani, Fumio; Araki, Yutaka; Tsukaguchi, Isao; Abe, Hiroshi ^[1]

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1. Osaka Rosai Hospital (Japan)

We compared three-dimensional time-of-flight MR angiograms obtained before and after acetazolamide administration to evaluate whether use of this drug could improve visualization of small peripheral intracranial arteries and atherosclerotic stenosis. For evaluation of small peripheral arteries, 10 patients with clinical diagnosis of ischemic cerebrovascular disease and 10 healthy volunteers were investigated, and for evaluation of stenosis, another 6 patients were investigated. Vascular images were obtained by three-dimensional time-of-flight MR angiography. After a baseline scan, 17 mg/kg acetazolamide was injected intravenously and the second scan was performed 20 minutes later. Several small peripheral arteries that had not been seen on the baseline images were visible on the acetazolamide images without any augmentation of the background signals. Stenotic lesions in the main trunks of the major cerebral arteries were detected more clearly on acetazolamide images. Acetazolamide improves visualization of small peripheral intracranial arteries and sensitivity in detecting atherosclerotic stenosis in the main trunk of major cerebral artery by three-dimensional time-of-flight MR angiography without changing MR apparatus and software. 15 refs., 5 figs., 2 tabs.

• OSTI ID: 6442822
• Journal Information: AJNR. American Journal of Neuroradiology; (United States), Journal Name: AJNR. American Journal of Neuroradiology; (United States) Vol. 15:4; ISSN 0195-6108; ISSN AAJNDL
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
ARTERIOSCLEROSIS
BIOMEDICAL RADIOGRAPHY
BLOOD FLOW
BLOOD VESSELS
BODY
BRAIN
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CEREBRAL ARTERIES
CONTRAST MEDIA
DIAGNOSTIC TECHNIQUES
DISEASES
MEDICINE
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
RADIOLOGY
TIME-OF-FLIGHT METHOD
VASCULAR DISEASES
VASODILATION