Proton microprobe and particle induced X-ray emission (PIXE) analysis for studies of pathological brain tissue

Journal Article · Thu Sep 01 04:00:00 EDT 1988 · Scan. Microsc.; (United States)

OSTI ID:6442495

Malmqvist, K G; Brun, A; Inamura, K; Martins, E; Salford, L G; Siesjoe, B K.T.; Tapper, U A; Themner, K

Particle Induced X-ray Emission and proton microprobe analyses have been applied for the investigation of regional elemental distributions in connection with various pathological states in the brain. Malignant brain tumors and adjacent histologically intact tissue removed during surgery were analysed with PIXE. Systematic elemental variations, e.g., for calcium and selenium, were observed in the tumor front. The proton microprobe was applied to study the Ca and K concentrations in various cell strata in hippocampus following transient ischaemia in rat brain. Significant increases in the Ca level occurred in selectively vulnerable cells within 48 h after the ischaemia.

• Research Organization: Dept. Nuclear Physics, Lund (Sweden)
• OSTI ID: 6442495
• Journal Information: Scan. Microsc.; (United States), Journal Name: Scan. Microsc.; (United States) Vol. 2:3; ISSN SCMIE
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALI METALS
ALKALINE EARTH METALS
ANIMALS
BODY
BRAIN
CALCIUM
CENTRAL NERVOUS SYSTEM
CHEMICAL ANALYSIS
CHEMICAL COMPOSITION
DISEASES
ELECTRON MICROPROBE ANALYSIS
ELEMENTS
MAMMALS
METALS
MICROANALYSIS
NEOPLASMS
NERVOUS SYSTEM
NONDESTRUCTIVE ANALYSIS
ORGANS
PATHOLOGY
POTASSIUM
QUANTITATIVE CHEMICAL ANALYSIS
RATS
RODENTS
VERTEBRATES
X-RAY EMISSION ANALYSIS