Two new rodent models for actinide toxicity studies. [/sup 237/Pu, /sup 241/Am]

Journal Article · Wed Apr 01 00:00:00 EST 1981 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575603· OSTI ID:6442262

Taylor, G N; Jones, C W; Gardner, P A; Lloyd, R D; Mays, C W; Charrier, K E

Two small rodent species, the grasshopper mouse (Onychomys leucogaster) and the deer mouse (Peromyscus maniculatus), have tenacious and high retention in the liver and skeleton of plutonium and americium following intraperitoneal injection of Pu and Am in citrate solution. Liver retention of Pu and Am in the grasshopper mouse is higher than liver retention in the deer mouse. Both of these rodents are relatively long-lived, breed well in captivity, and adapt suitably to laboratory conditions. It is suggested that these two species of mice, in which plutonium retention is high and prolonged in both the skeleton and liver, as it is in man, may be useful animal models for actinide toxicity studies.

• Research Organization: Univ. of Utah, Salt Lake City
• DOE Contract Number: AC02-76EV00119
• OSTI ID: 6442262
• Journal Information: Radiat. Res.; (United States), Vol. 86:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMERICIUM 241
RETENTION
LIVER
RADIONUCLIDE KINETICS
PLUTONIUM 237
BIOLOGICAL MODELS
SKELETON
CITRATES
MICE
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
AMERICIUM ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACID SALTS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLANDS
HEAVY NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PLUTONIUM ISOTOPES
RADIOISOTOPES
RODENTS
SECONDS LIVING RADIOISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)