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Successful therapy of herpes hominis keratitis in rabbits by 5-10D0-5'-amino-2'5'-dideoxyuridine (AIU): a novel analog of thymidine

Journal Article · · Invest. Ophthalmol.; (United States)
OSTI ID:6433733
; ; ; ; ; ; ; ;

The efficiency of 5-iodo-5'-amino-2'5'-dideoxyuridine (AIU) in the therapy of experimental herpes keratitis in rabbits has been examined. Virus infections were established bilaterally in 40 animals using herpes simplex, type 1 (NIH strain 11124). Twenty-four hours after infection the rabbits were divided into five matched groups of eight and each group was treated, double-blind, with topical drugs at four-hour intervals for a total of 72 hours. The solutions instilled were: saline; IdUrd, 1 mg. per milliliter); AIU, 1 mg. per milliliter; AIU, 4 mg. per milliliter; and AIU, 8 mg. per milliliter. Each eye was examined daily for 12 days and graded independently by two ophthalmologists. Although IdUrd and AIU (8 mg. per milliliter were effective therapeutically, IdUrd had a greater effect. The AIU at 1 and 4 mg. per milliliter were less active, but showed more rapid healing than the saline control. Viral recovery studies are consistent with the clinical observations. A second independent experiment, similar to that described above, gave essentially identical results. Although less potent than IdUrd, AIU does providee effective therapy for herpes keratitis.

Research Organization:
Yale Univ., New Haven, CT
OSTI ID:
6433733
Journal Information:
Invest. Ophthalmol.; (United States), Journal Name: Invest. Ophthalmol.; (United States) Vol. 15:6; ISSN INOPA
Country of Publication:
United States
Language:
English

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Related Subjects

550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ANTIMETABOLITES
ANTIMITOTIC DRUGS
AZINES
BODY
DISEASES
DRUGS
EYES
HERPES SIMPLEX
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INFECTIOUS DISEASES
INJURIES
IODODEOXYURIDINE
IODOURACILS
MAMMALS
MICROORGANISMS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PARASITES
PYRIMIDINES
RABBITS
RIBOSIDES
SENSE ORGANS
SKIN DISEASES
THERAPY
URACILS
VERTEBRATES
VIRUSES