Single dose x irradiation and concomitant hyperthermia on a murine fibroscarcoma. [Sensitizing effects of hyperthermia on tumors in mice subjected to local radiotherapy]

Journal Article · Fri Dec 01 00:00:00 EST 1978 · Cancer; (United States)

OSTI ID:6432498

Hahn, E W; Alfieri, A A; Kim, J H

The objectives of this study were to quantitate the effects of local tumor hyperthermia (LTH) and concomitant x irradiation (RAD) on a moderately radioresistant murine fibrosarcoma in situ. Comparisons were made to the combined treatment response on the Ridgway osteogenic sarcoma, a radiosensitive tumor previously used in this laboratory and to establish the Meth-A fibrosarcoma as a model system for combined modality studies. 1.0 cm/sup 3/ tumors were exposed to single doses of RAD ranging from 0.5 to 3.8 krad alone or 0.5 to 2.3 krad in combination with LTH (water bath at 43.1 +- .05 C for 20 minutes) applied immediately postirradiation. LTH significantly enhanced the action of radiation as measured by tumor volume analysis, mean survival time and cures. The ratio of radiation doses vs. RAD + LTH required to produce an equivalent response ranged from 1.4 to 2.5 depending upon the endpoints evaluated. These findings are consistent with single dose studies on the radiosensitive Ridgway osteogenic sarcoma and suggest that the tumoricidal effectiveness of combination radiation and hyperthermia cannot be predicted on the basis of the radiation alone responsiveness of tumor.

• Research Organization: Sloan Kettering Inst., New York, NY
• OSTI ID: 6432498
• Journal Information: Cancer; (United States), Vol. 42:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
FIBROSARCOMAS
BIOLOGICAL RADIATION EFFECTS
HYPERTHERMIA
RADIOSENSITIVITY EFFECTS
RADIOSENSITIVITY
TEMPERATURE EFFECTS
TUMOR CELLS
ACUTE IRRADIATION
LEGS
LOCAL IRRADIATION
MICE
RADIOTHERAPY
X RADIATION
ACUTE EXPOSURE
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
BODY AREAS
BODY TEMPERATURE
DISEASES
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
IRRADIATION
LIMBS
MAMMALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RODENTS
SARCOMAS
THERAPY
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
550603 - Medicine- External Radiation in Therapy- (1980-)