Effects of supplemental mangesium on blood and tissue lead levels and toxicity of ingested lead in the rat

Conference · Mon Jun 01 04:00:00 EDT 1981 · Trace Subst. Environ. Health; (United States)

OSTI ID:6428417

Mylroie, A A; Hickmon, T; Hill, G

Dietary magnesium supplementation has been reported to lower retention and to increase excretion of lead in Pb treated rats, thus reducing the total body burden and the toxic effects of Pb. In order to determine the effects of Mg in our studies, purified diet containing 0.05% Mg was supplemented with 0.1% Mg (as MgO) and fed to groups of weanling Sprague Dawley rats; Pb was added to the drinking water (0, 250, 500 and 1000 ppM Pb(C/sub 2/H/sub 3/O/sub 2/ 3H/sub 2/O) for 5 to 6 weeks in a series of experiments. Blood levels were exceedingly high (10 to 28 mg Pb/ml) at the end of the experimental period compared to values (0.9 to 2.4 ..mu..g Pb/ml) obtained in rats receiving unsupplemented diet. Similarly, spleen Pb, like blood Pb levels, were up to 20 times higher in rats fed Mg supplemented diet. Lead levels increased in liver (80 to 400%) and brain (17 to 100%); bone and kidney Pb concentrations were unchanged in one experiment (5 weeks) but increased in a second experiment (6 weeks) as a result of Mg supplementation. Increases in tissue Pb levels were not accompanied by comparable increases in Pb induced anemia. Magnesium supplementation (0.1%) of a nutritionally adequate purified diet, at a total conc of Mg that is lower than in stock diets like Purina Chow (0.2% Mg), results in an increased body burden of Pb and unprecedented high blood and spleen Pb levels under the experimental conditions.

• Research Organization: Chicago State Univ., IL
• OSTI ID: 6428417
• Report Number(s): CONF-8106251-
• Conference Information: Journal Name: Trace Subst. Environ. Health; (United States) Journal Volume: 15
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
DISTRIBUTION
DRINKING WATER
ELEMENTS
HYDROGEN COMPOUNDS
LEAD
MAGNESIUM
MAMMALS
MATERIALS
METABOLISM
METALS
ORGANS
OXYGEN COMPOUNDS
RATS
RODENTS
SENSITIVITY
SPLEEN
TISSUE DISTRIBUTION
TOXICITY
VERTEBRATES
WATER