Neurologic complications of polycythemia and their impact on therapy

Journal Article · Thu Mar 01 00:00:00 EST 1990 · Oncology (Williston Park, N.Y.); (USA)

OSTI ID:6427387

Newton, L K ^[1]

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1. MD Anderson Cancer Center, Houston, TX (USA)

Polycythemia vera, a clonal stem cell disorder, produces neurologic problems in 50-80% of patients. Some symptoms, such as headache and dizziness, are related to hyperviscosity, and respond immediately to reduction of cell counts. Others seem to result from an associated coagulopathy. Patients with polycythemia tend to develop both arterial and venous thrombosis and are prone to hemorrhages. Treatments for polycythemia include phlebotomy, chlorambucil supplemented with phlebotomy, and {sup 32}P plus phlebotomy. Whatever treatment is chosen, the aim of therapy should be to reduce the hematocrit to approximately 40-45%.37 references.

• OSTI ID: 6427387
• Journal Information: Oncology (Williston Park, N.Y.); (USA), Vol. 4:3; ISSN 0890-9091
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
NERVOUS SYSTEM DISEASES
COMBINED THERAPY
THROMBOSIS
BLOOD COUNT
CHLORAMBUCIL
PATIENTS
PHOSPHORUS 32
REVIEWS
STEM CELLS
SURGERY
SYMPTOMS
AMINES
ANIMAL CELLS
ANTINEOPLASTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
DAYS LIVING RADIOISOTOPES
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DOCUMENT TYPES
DRUGS
ISOTOPES
LIGHT NUCLEI
MEDICINE
MONOCARBOXYLIC ACIDS
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PHOSPHORUS ISOTOPES
RADIOISOTOPES
SOMATIC CELLS
THERAPY
VASCULAR DISEASES
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