Effects on rat lung immunity by acute lung exposure to benzo(a)pyrene

Journal Article · Thu Jul 01 00:00:00 EDT 1982 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1982.10667565· OSTI ID:6425311

Schnizlein, C T ^[1]; Bice, D E; Mitchell, C E; Hahn, F F

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1. Medical Coll. of Virginia, Richmond

This study describes the effect of intratracheal instillation of benzo(a)pyrene (BaP) on immunological responses in the lung-associated lymph nodes, cervical lymph nodes, and spleen after deposition of 10/sup 8/ sheep red blood cells (SRCB) in the lung or peritoneal cavity of rats. An increased number of anti-SRBC antibody-forming cells was observed in the lung-assoicated lymph nodes when rats were immunized simultaneously with BaP instillation. A suppression in the number of anti-SRBC antibody-forming cells occurred when SRBC were given intratracheally 4 or 7 days after BaP. The effects of the BaP appeared to be on the function of the cells in the lung-associated lymph nodes rather than due to changes in the exposed lung. BaP-induced changes in antigen handling or in regulatory populations of immune cells in the lung-associated lymph nodes may be responsible for the immune alterations observed.

• DOE Contract Number: AC04-76EV01013
• OSTI ID: 6425311
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 37:4; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ANIMALS
ANTIBODY FORMATION
AROMATICS
BENZOPYRENE
BIOLOGICAL EFFECTS
BODY
CONDENSED AROMATICS
HYDROCARBONS
IMMUNE REACTIONS
IMMUNITY
IMMUNOSUPPRESSION
INTRATRACHEAL ADMINISTRATION
LUNGS
LYMPH NODES
LYMPHATIC SYSTEM
MAMMALS
ORGANIC COMPOUNDS
ORGANS
RATS
RESPIRATORY SYSTEM
RODENTS
SPLEEN
VERTEBRATES