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Myocardial damage following transthoracic direct current countershock in newborn piglets

Journal Article · · Pediatr. Cardiol.; (United States)
DOI:https://doi.org/10.1007/BF02426974· OSTI ID:6425081
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The effect of transthoracic direct current countershock on the myocardium of 21 newborn piglets was studied. Myocardial damage was quantified by measuring the myocardial uptake of technetium-99m pyrophosphate injected 24 hours after countershock. Substantial myocardial damage occurred in animals given greater than 150 joules/kg but not at lower energy doses. Damage occurred in both ventricular free walls, but more frequently in the right ventricle. The epicardial half of the myocardium was more severely affected than the endocardial half. The relationship between myocardial damage and total countershock energy dose was well modeled by an exponential function. Transthoracic direct current countershock appears unlikely to cause myocardial damage in newborn piglets unless greatly elevated energy doses are employed.

Research Organization:
Department of Pediatrics, Yale University School of Medicine, New Haven, CT
OSTI ID:
6425081
Journal Information:
Pediatr. Cardiol.; (United States), Journal Name: Pediatr. Cardiol.; (United States) Vol. 2:4; ISSN PECAD
Country of Publication:
United States
Language:
English

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560400* -- Other Environmental Pollutant Effects
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
BODY AREAS
CARDIOVASCULAR SYSTEM
CHEST
DOMESTIC ANIMALS
DOSE-RESPONSE RELATIONSHIPS
ELECTRIC SHOCK
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
PYROPHOSPHATES
RADIOISOTOPES
SWINE
TECHNETIUM 99
TECHNETIUM ISOTOPES
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES