Generation of protein-specific and alloantigen-specific suppressor cells following total lymphoid irradiation in mice
The presence of donor-type specific suppressor cells was demonstrated in C57BL/Ka ..-->.. BALB/c BM chimeras in both in vivo and in vitro experiments. In both experiments tolerance to either BSA of C57BL/Ka tissue antigens could be transferred into adoptive recipients. In view of the data obtained in BSA-tolerant mice, it is likely that the suppressor cells in the chimeras were also T cells in origin; however, formal proof has yet to be obtained. We conclude that antigen-specific suppressor cells are generated following TLI. Specific transplantation tolerance obtained by immunomanipulation rather than by prolonged use of nonspecific immunosuppressive agents is the goal of clinical BM and organ transplantation. Due to the experience accumulated in patients with Hodgkin's disease regarding the effects and relative safety of using TLI, it may soon become a new clinical tool for BM and organ transplantation in man.
- Research Organization:
- Hebrew Univ., Jerusalem, Israel
- OSTI ID:
- 6424400
- Journal Information:
- Transplant. Proc.; (United States), Journal Name: Transplant. Proc.; (United States) Vol. 11:1; ISSN TICPB
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
CHIMERAS
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
IMMUNE REACTIONS
IMMUNOSUPPRESSION
IRRADIATION
MAMMALS
MICE
MOSAICISM
ORGANS
RADIATION CHIMERAS
RADIATION EFFECTS
RODENTS
SOMATIC CELLS
THYMOCYTES
TISSUES
TRANSPLANTS
VERTEBRATES
WHOLE-BODY IRRADIATION