Effect of chain density on inhibition of protein adsorption by poly(ethylene glycol) based coatings
Journal Article
·
· Journal of Colloid and Interface Science
- Inst. for Surface Chemistry, Stockholm (Sweden)
- Univ. of Alabama, Huntsville, AL (United States). Dept. of Chemistry
- Royal Inst. of Tech., Stockholm (Sweden). Dept. of Chemical Engineering and Technology
The effect of interfacial chain density of poly(ethylene glycol) (PEG) on the adsorption of serum proteins was investigated by in situ ellipsometry. For terminal covalently grafted PEG of molecular weight 5,000 an increased grafting density results in decreased serum protein adsorption. At high interfacial chain density ({approx}0.1 chain/nm{sup 2}), efficient protein injection was observed, irrespective of the coupling chemistry used. Strongly adsorbed PEG-containing polymers behaved similarly to covalently attached PEG regarding inhibition of protein adsorption, independent of the nature of the underlying surface. The results are discussed in relation to the importance of the protein size in protein rejection by PEG coatings.
- Sponsoring Organization:
- National Science Foundation, Washington, DC (United States); National Aeronautics and Space Administration, Washington, DC (United States)
- OSTI ID:
- 642286
- Journal Information:
- Journal of Colloid and Interface Science, Journal Name: Journal of Colloid and Interface Science Journal Issue: 2 Vol. 202; ISSN 0021-9797; ISSN JCISA5
- Country of Publication:
- United States
- Language:
- English
Similar Records
Surface Mechanical and Rheological Behaviors of Biocompatible Poly((D,L-lactic acid-ran-glycolic acid)-block-ethylene glycol) (PLGA-PEG) and Poly((D,L-lactic acid-ran-glycolic acid-ran-ε-caprolactone)-block-ethylene glycol) (PLGACL-PEG) Block Copolymers at the Air-Water Interface
Effect of Poly(ethylene glycol) Grafting Density on Methylcellulose Fibril Formation
Unusual Effect of Iodine Ions on the Self-Assembly of Poly(ethylene glycol)-Capped Gold Nanoparticles
Journal Article
·
Sun Jan 31 23:00:00 EST 2016
· Langmuir
·
OSTI ID:1236861
Effect of Poly(ethylene glycol) Grafting Density on Methylcellulose Fibril Formation
Journal Article
·
Wed Nov 14 19:00:00 EST 2018
· Macromolecules
·
OSTI ID:1492985
Unusual Effect of Iodine Ions on the Self-Assembly of Poly(ethylene glycol)-Capped Gold Nanoparticles
Journal Article
·
Sat Dec 14 19:00:00 EST 2019
· Langmuir
·
OSTI ID:1593153