Cerebral ischemia produced by four-vessel occlusion in the rat: a quantitative evaluation of cerebral blood flow

Journal Article · · Stroke; (United States)

DOI:https://doi.org/10.1161/01.STR.13.6.852· OSTI ID:6422209

Furlow, Jr, T W

Cerebral ischemia was produced in the rat by simultaneous occlusion of the vertebral and carotid arteries according to the method of Pulsinelli and Brierley (Stroke 10: 267, 1979). Local cerebral blood flow (CBF) was determined by polarographic and autoradiographic techniques. Hydrogen-clearance measurements showed that mean CBF fell in four monitored regions of the hemispheres to between 0.11 and 0.18 ml/g/min, being least in deep rostal gray, intermediate in superficial gray, and greatest in deep caudal gray. However, individual animals had local CBF in excess of 0.20 and even 0.30 ml/g/min, and no animal showed zero CBF. When animals were rendered hypotensive (MABP of 50 Torr) during vascular occlusion, mean CBF ranged between 0.03 and 0.10 ml/g/min in the same regional order. With hypotension, total arrest of flow occurred. Autoradiographic data confirmed the above findings and indicated adequate CBF to the lower brainstem. During vascular occlusion, sufficient CBF may be present ot sustain cerebral tissue as in animals with a well developed spinal circulation or an inadvertently patent vertebral artery.

• Research Organization: Department of Neurology, University of Alabama in Birmingham
• OSTI ID: 6422209
• Journal Information: Stroke; (United States), Journal Name: Stroke; (United States) Vol. 13:6; ISSN SJCCA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ARTERIES
BLOOD FLOW
BLOOD VESSELS
BODY
BRAIN
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CAROTID ARTERIES
CENTRAL NERVOUS SYSTEM
CEREBRUM
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
ISCHEMIA
MAMMALS
NERVOUS SYSTEM
ORGANS
PATHOLOGY
RADIOISOTOPE SCANNING
RATS
RODENTS
SCINTISCANNING
VASCULAR DISEASES
VERTEBRATES