Radioimmune imaging of bone marrow in patients with suspected bone metastases from primary breast cancer

Journal Article · Sat Sep 01 00:00:00 EDT 1990 · Journal of Nuclear Medicine; (USA)

OSTI ID:6421836

Duncker, C M; Carrio, I; Berna, L; Estorch, M; Alonso, C; Ojeda, B; Blanco, R; Germa, J R; Ortega, V ^[1]

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1. Hospital de Sant Pau, Barcelona (Spain)

Radioimmune imaging of bone marrow was performed by technetium-99m- (99mTc) labeled antigranulocyte monoclonal antibody BW 250/183 (AGMoAb) scans in 32 patients with suspected bone metastases from primary breast cancer. AGMoAb scans showed bone marrow defects in 25/32 (78%) patients; bone invasion was subsequently confirmed in 23 (72%) patients. Conventional bone scans performed within the same week detected bone metastases in 17/32 (53%) patients (p less than 0.001). AGMoAb scans detected more sites indicating metastatic disease than bone scans in 12 of these 17 patients (71%). All patients with bone metastases in the axial skeleton had bone marrow defects at least at the sites of bone metastases. Of 15 patients with normal, or indicative of, benign disease bone scans, 8 patients (53%) presented with bone marrow defects in the AGMoAb scans. Bone invasion was confirmed in six of them. AGMoAb bone marrow scans provide a method for the early detection of bone metastatic invasion in patients with breast cancer and suspected bone metastases.

• OSTI ID: 6421836
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 31:9; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BONE MARROW
RADIOIMMUNOSCINTIGRAPHY
MAMMARY GLANDS
NEOPLASMS
METASTASES
DIAGNOSIS
SKELETON
ISOMERIC NUCLEI
MONOCLONAL ANTIBODIES
PATIENTS
TECHNETIUM 99
ANIMAL TISSUES
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
GLANDS
HEMATOPOIETIC SYSTEM
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOIMMUNODETECTION
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TECHNETIUM ISOTOPES
TISSUES
TRACER TECHNIQUES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics