Identification of organic N-chloramines in vitro in stomach fluid from the rate after chlorination

Journal Article · · Chemical Research in Toxicology; (USA)

OSTI ID:6411409

Scully, Jr, F E; Mazina, K E ^[1]; Ringhand, H P ^[2]; Chess, E K; Campbell, J A ^[3]; Johnson, J D ^[4]

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1. Old Dominion Univ., Norfolk, VA (USA)
2. Environmental Protection Agency, Cincinnati, OH (USA)
3. Battelle Pacific Northwest Laboratories, Richland, WA (USA)
4. Univ. of North Carolina, Chapel Hill (USA)

Amino acids were identified and quantified in the stomach fluid recovered from animals fasted 8, 24, and 48 h. After in vitro chlorination of stomach fluid, three chloramino acids, N-chloroglycine, either N-chloroleucine or N-chloroisoleucine, and N-chlorophenylalanine, were identified by GC/MS analysis of dansylated methyl ester derivatives. Formation of N-chlorovaline and N-chloroserine was suggested by their HPLC retention times, but their identification could not be confirmed by GC/MS data.

• OSTI ID: 6411409
• Journal Information: Chemical Research in Toxicology; (USA), Journal Name: Chemical Research in Toxicology; (USA) Vol. 3:4; ISSN CRTOE; ISSN 0893-228X
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
AMINO ACIDS
AQUEOUS SOLUTIONS
CARBOXYLIC ACIDS
CHEMICAL ANALYSIS
CHLORAMINES
CHLORINE
CHROMATOGRAPHY
DISPERSIONS
ELEMENTS
GAS CHROMATOGRAPHY
HALOGENS
IN VITRO
MASS SPECTROSCOPY
MIXTURES
NONMETALS
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
SEPARATION PROCESSES
SOLUTIONS
SPECTROSCOPY
TOXICITY