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Title: Atrial natriuretic peptide stimulates salt secretion by shark rectal gland by releasing VIP

Abstract

Salt secretion by the isolated perfused rectal gland of the spiny dogfish shark, Squalus acanthias, is stimulated by synthetic rat atrial natriuretic peptide (ANP II) as well as extracts of shark heart, but not by 8-bromo-cyclic guanosine 5'-monophosphate. Cardiac peptides have no effect on isolated rectal gland cells or perfused tubules, suggesting that stimulation requires an intact gland. The stimulation of secretion by ANP II is eliminated by maneuvers that block neurotransmitter release. Cardiac peptides stimulate the release of vasoactive intestinal peptide (VIP), known to be present in rectal glands nerves, into the venous effluent of perfused glands in parallel with their stimulation of salt secretion, but the release of VIP induced by ANP II is prevented by perfusion with procaine. VIP was measured by radioimmunoassay. Cardiac peptides thus appear to regulate rectal gland secretion by releasing VIP from neural stores within the gland. It is possible that other physiological effects of these hormones might be explained by an action to enhanced local release of neurotransmitters.

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Harvard Medical School, Boston, MA
OSTI Identifier:
6410444
Resource Type:
Journal Article
Journal Name:
Am. J. Physiol.; (United States)
Additional Journal Information:
Journal Volume: 252:1
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; PEPTIDES; RADIOIMMUNOASSAY; SALTS; SECRETION; CALCIUM COMPOUNDS; HEART; HORMONES; IODINE 125; MAGNESIUM COMPOUNDS; ORGANS; PHYSIOLOGY; ULTRAFILTRATION; VERTEBRATES; ALKALINE EARTH METAL COMPOUNDS; ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR SYSTEM; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; FILTRATION; IMMUNOASSAY; IMMUNOLOGY; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PROTEINS; RADIOASSAY; RADIOIMMUNOLOGY; RADIOISOTOPES; SEPARATION PROCESSES; TRACER TECHNIQUES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 551001 - Physiological Systems- Tracer Techniques

Citation Formats

Silva, P., Stoff, J.S., Solomon, R.J., Lear, S., Kniaz, D., Greger, R., and Epstein, F.H. Atrial natriuretic peptide stimulates salt secretion by shark rectal gland by releasing VIP. United States: N. p., 1987. Web.
Silva, P., Stoff, J.S., Solomon, R.J., Lear, S., Kniaz, D., Greger, R., & Epstein, F.H. Atrial natriuretic peptide stimulates salt secretion by shark rectal gland by releasing VIP. United States.
Silva, P., Stoff, J.S., Solomon, R.J., Lear, S., Kniaz, D., Greger, R., and Epstein, F.H. Thu . "Atrial natriuretic peptide stimulates salt secretion by shark rectal gland by releasing VIP". United States.
@article{osti_6410444,
title = {Atrial natriuretic peptide stimulates salt secretion by shark rectal gland by releasing VIP},
author = {Silva, P. and Stoff, J.S. and Solomon, R.J. and Lear, S. and Kniaz, D. and Greger, R. and Epstein, F.H.},
abstractNote = {Salt secretion by the isolated perfused rectal gland of the spiny dogfish shark, Squalus acanthias, is stimulated by synthetic rat atrial natriuretic peptide (ANP II) as well as extracts of shark heart, but not by 8-bromo-cyclic guanosine 5'-monophosphate. Cardiac peptides have no effect on isolated rectal gland cells or perfused tubules, suggesting that stimulation requires an intact gland. The stimulation of secretion by ANP II is eliminated by maneuvers that block neurotransmitter release. Cardiac peptides stimulate the release of vasoactive intestinal peptide (VIP), known to be present in rectal glands nerves, into the venous effluent of perfused glands in parallel with their stimulation of salt secretion, but the release of VIP induced by ANP II is prevented by perfusion with procaine. VIP was measured by radioimmunoassay. Cardiac peptides thus appear to regulate rectal gland secretion by releasing VIP from neural stores within the gland. It is possible that other physiological effects of these hormones might be explained by an action to enhanced local release of neurotransmitters.},
doi = {},
journal = {Am. J. Physiol.; (United States)},
number = ,
volume = 252:1,
place = {United States},
year = {1987},
month = {1}
}