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Stimulation of S14 mRNA and lipogenesis in brown fat by hypothyroidism, cold exposure, and cafeteria feeding: evidence supporting a general role for S14 in lipogenesis and lipogenesis in the maintenance of thermogenesis

Journal Article · · Proc. Natl. Acad. Sci. U.S.A.; (United States)
;
In liver, thyroid hormone rapidly induces S14 mRNA, which encodes a small acidic protein. This sequence is abundantly expressed only in lipogenic tissues and is thought to have some function in fat metabolism. In the euthyroid rat, we measured 20-fold higher levels of S14 mRNA in interscapular brown adipose tissue than liver. Furthermore, whereas in liver or epididymal fat, hypothyroidism resulted in an 80% fall in S14 mRNA, in brown fat the level of this sequence increased a further 3-fold. In all three tissues, the expression of S14 mRNA correlated well with lipogenesis, as assessed by /sup 3/H/sub 2/O incorporation. Physiological activation of brown fat by chronic cold exposure or cafeteria feeding increased the concentration of S14 mRNA in this tissue and again this was accompanied by a greater rate of fatty acid synthesis. Overall, in liver and white and brown adipose tissue, S14 mRNA and lipogenesis were well correlated and strongly suggest a function of the S14 protein related to fat synthesis. These studies suggest that the S14 protein and lipogenesis may be important for thyroid hormone-induced and brown adipose tissue thermogenesis and that stimulation of these functions in hypothyroid brown fat is a consequence of decreased thyroid hormone-induced thermogenesis elsewhere.
Research Organization:
Univ. of Minnesota, Minneapolis
OSTI ID:
6409434
Journal Information:
Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 9; ISSN PNASA
Country of Publication:
United States
Language:
English

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Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADIPOSE TISSUE
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL FUNCTIONS
BIOLOGICAL LOCALIZATION
BIOSYNTHESIS
BODY
BODY TEMPERATURE
CARBOXYLIC ACIDS
CONNECTIVE TISSUE
DIET
DIGESTIVE SYSTEM
DISEASES
ENDOCRINE DISEASES
FUNCTIONS
GLANDS
HORMONES
HYPERTHYROIDISM
HYPOTHYROIDISM
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIPIDS
LIVER
MAMMALS
MESSENGER-RNA
METABOLISM
NUCLEIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PEPTIDE HORMONES
PROTEINS
RATS
RESPONSE MODIFYING FACTORS
RNA
RODENTS
SYNTHESIS
THYROID HORMONES
THYROXINE
TISSUES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES