How do cancer risks predicted from animal bioassays compare with the epidemiologic evidence. The case of ethylene dibromide

Journal Article · Wed Jun 01 00:00:00 EDT 1988 · Risk Anal.; (United States)

DOI:https://doi.org/10.1111/j.1539-6924.1988.tb01173.x· OSTI ID:6408567

Hertz-Picciotto, I; Gravitz, N; Neutra, R

Cancer risks for ethylene dibromide (EDB) were estimated by fitting several linear nonthreshold additive models to data from a gavage bioassay. Risks predicted by these models were compared to the observed cancer mortality among a cohort of workers occupationally exposed to the same chemical. Models that accounted for the shortened latency period in the gavaged rats predicted upper bound risks that were within a factor of 3 of the observed cancer deaths. Data from an animal inhalation study of EDB also were compatible with the epidemiologic data. These findings contradict those of Ramsey et al. (1978), who reported that extrapolation from animal data produced highly exaggerated risk estimates for EDB-exposed workers. This paper explores the reasons for these discrepant findings.

• Research Organization: California Public Health Foundation, Berkeley (USA)
• OSTI ID: 6408567
• Journal Information: Risk Anal.; (United States), Vol. 8:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BROMINATED ALIPHATIC HYDROCARBONS
BIOLOGICAL EFFECTS
CARCINOGENS
RISK ASSESSMENT
LABORATORY ANIMALS
BIOASSAY
NEOPLASMS
EPIDEMIOLOGY
COMPARATIVE EVALUATIONS
CORRELATIONS
DATA COVARIANCES
DEATH
DOSE-RESPONSE RELATIONSHIPS
INHALATION
MICE
MORTALITY
OCCUPATIONAL EXPOSURE
PERSONNEL
RATS
STATISTICAL MODELS
ANIMALS
DISEASES
HALOGENATED ALIPHATIC HYDROCARBONS
INTAKE
MAMMALS
MATHEMATICAL MODELS
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology