Effects of repeated inhalation of sulfuric acid aerosol on tracheobronchial structure and function in rabbits
Thesis/Dissertation
·
OSTI ID:6408140
This investigation evaluated the responses of the rabbit tracheobronchial system to daily exposures of sulfuric acid aerosol, in an attempt to correlate in vivo physiologic responses with structural changes determined histologically. The changes in tracheobronchial mucociliary clearance of /sup 99m/Tc tagged iron oxide particles was evaluated in 40 New Zealand White rabbits exposed to 250 ug/m/sup 3/ 1 hr/day, with sacrifices of 5 acid and 5 control rabbits, after 4, 8, and 12 months of acid exposure; remaining rabbits were allowed a three month recovery from acid exposure. Sulfuric acid produced a slowing in mucociliary clearance in the first week of exposure, that became significantly worse as the number of acid exposures continued. An increase in the slope of the slowing of clearance with increased number of exposures occurred by the twelfth month of acid exposure and this increase in slope of slowed clearance continued to worsen for the recovery group.
- Research Organization:
- New York Univ., NY (USA)
- OSTI ID:
- 6408140
- Country of Publication:
- United States
- Language:
- English
Similar Records
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Physiological and histological alterations in the bronchial mucociliary clearance system of rabbits following intermittent oral or nasal inhalation of sulfuric acid mist
Journal Article
·
Tue Jan 31 23:00:00 EST 1989
· Environ. Health Perspect.; (United States)
·
OSTI ID:5900719
Long-term intermittent exposure to sulfuric acid aerosol, ozone, and their combination: alterations in tracheobronchial mucociliary clearance and epithelial secretory cells
Journal Article
·
Wed Jul 01 00:00:00 EDT 1992
· Experimental Lung Research; (United States)
·
OSTI ID:6992933
Physiological and histological alterations in the bronchial mucociliary clearance system of rabbits following intermittent oral or nasal inhalation of sulfuric acid mist
Journal Article
·
· J. Toxicol. Environ. Health; (United States)
·
OSTI ID:6846734
Related Subjects
550901 -- Pathology-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CLEARANCE
COLLOIDS
DISEASES
DISPERSIONS
EXCRETION
HOURS LIVING RADIOISOTOPES
HYDROGEN COMPOUNDS
INHALATION
INORGANIC ACIDS
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LUNG CLEARANCE
LUNGS
MAMMALS
MORPHOLOGICAL CHANGES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RABBITS
RADIOISOTOPES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SENSITIVITY
SOLS
SULFURIC ACID
TECHNETIUM 99
TECHNETIUM ISOTOPES
TOXICITY
TRACER TECHNIQUES
ULTRASTRUCTURAL CHANGES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CLEARANCE
COLLOIDS
DISEASES
DISPERSIONS
EXCRETION
HOURS LIVING RADIOISOTOPES
HYDROGEN COMPOUNDS
INHALATION
INORGANIC ACIDS
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LUNG CLEARANCE
LUNGS
MAMMALS
MORPHOLOGICAL CHANGES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RABBITS
RADIOISOTOPES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SENSITIVITY
SOLS
SULFURIC ACID
TECHNETIUM 99
TECHNETIUM ISOTOPES
TOXICITY
TRACER TECHNIQUES
ULTRASTRUCTURAL CHANGES
VERTEBRATES
YEARS LIVING RADIOISOTOPES