Cerebral glucose metabolism in the course of subacute sclerosing panencephalitis

Journal Article · Sun Jan 01 04:00:00 EST 1989 · Arch. Neurol.; (United States)

DOI:https://doi.org/10.1001/archneur.1989.00520370099029· OSTI ID:6406763

Huber, M; Herholz, K; Pawlik, G; Szelies, B; Juergens, R H; Heiss, W D

Regional cerebral glucose metabolism was studied in a 15-year-old boy with subacute sclerosing panencephalitis before and after therapy with human interferon beta, using positron emission tomography of fluorine 18-2-fluoro-2-deoxyglucose. At first examination, metabolism was symmetrically decreased in the thalamus, cerebellum, and all cortical areas except prerolandic motor cortex, but increased in lentiform nucleus. A computed tomographic scan was normal. Six months later, bilateral focal necrosis centered in the previously hypermetabolic putamen was demonstrated by computed tomography and magnetic resonance imaging. The caudate nucleus and the superoposterior part of the putamen were spared, still showing increased metabolism. Corresponding with some clinical improvement, cortical glucose consumption rates had returned to a normal level.

• Research Organization: Max-Planck-Institut fuer Neurologische Forschung, Cologne (West Germany)
• OSTI ID: 6406763
• Journal Information: Arch. Neurol.; (United States), Journal Name: Arch. Neurol.; (United States) Vol. 46:1; ISSN ARNEA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
ENCEPHALITIS
FLUORINE 18
FLUORINE ISOTOPES
GLUCOSE
GROWTH FACTORS
HEXOSES
HOURS LIVING RADIOISOTOPES
IMAGE PROCESSING
INFECTIOUS DISEASES
INTERFERON
ISOTOPES
LIGHT NUCLEI
LYMPHOKINES
METABOLISM
MITOGENS
MONOSACCHARIDES
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NMR IMAGING
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
POSITRON COMPUTED TOMOGRAPHY
PROCESSING
PROTEINS
RADIOISOTOPES
SACCHARIDES
TOMOGRAPHY
VIRAL DISEASES