Lymphoscintigraphy in melanoma patients using Tc-99m dextran

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6405210

Marciano, D; Padgett, H; Henze, E; Carlson, C; Bennett, L R

Surgical removal of regional lymph nodes draining the site of a melanoma is a generally practiced procedure. It is often difficult in many cases of truncal melanomas near the midline or near the waistline to determine which group or groups of nodes to remove. Colloidal Au-198, Tc-99m sulfur colloid, and Tc-99m antimony sulfur colloid have all been used and have given useful clinical information. Objections, however, have been raised to the local radiation dose with these compounds. To reduce this problem while obtaining greater information on lymph flow, the authors have studied dextran, a macromolecule commonly used as plasma substitute. Dextran (average mol. wt. 72,000) labeled with Tc-99m has been used to study lymph drainage from the site of truncal melanoma in 29 patients. Serial images in the first hour following intradermal injection clearly demonstrate tracer in efferent lymphatics within 5 to 10 minutes, and brief pooling in the regional lymph nodes between 20 and 60 minutes. When compared with particulate tracers such as micro Tc-99m sulfur colloid, the Tc-99m dextran appears to move much faster through the lymphatics. Overall distribution of the Tc-99m dextran to lymph nodes is very similar to previous findings with micro Tc-99m sulfur colloid. Dextran drainage to more than one group of regional nodes was seen in 12/29 patients as compared with 17/50 patients using micro Tc-99m sulfur colloid. The superior images with Tc-99m dextran appear to make it the agent of choice.

• Research Organization: UCLA School of Medicine, Los Angeles, CA
• OSTI ID: 6405210
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD SUBSTITUTES
CARBOHYDRATES
COLLOIDS
COUNTING TECHNIQUES
DEXTRAN
DIAGNOSTIC TECHNIQUES
DISEASES
DISPERSIONS
DISTRIBUTION
DOSIMETRY
DRUGS
DYNAMIC FUNCTION STUDIES
HEMATOLOGIC AGENTS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LYMPH NODES
LYMPH VESSELS
LYMPHATIC SYSTEM
MEDICINE
MELANOMAS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PATIENTS
POLYSACCHARIDES
RADIATION DOSE DISTRIBUTIONS
RADIOCOLLOIDS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
SACCHARIDES
SCINTISCANNING
SPATIAL DOSE DISTRIBUTIONS
SURGERY
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUE DISTRIBUTION
UPTAKE
YEARS LIVING RADIOISOTOPES