Extracorporeal complexing hemodialysis system for the treatment of methylmercury poisoning. II. In vivo applications in the dog

Journal Article · Sat Jan 01 04:00:00 EST 1977 · J. Pharmacol. Exp. Ther.; (United States)

OSTI ID:6405084

Kostyniak, P J; Clarkson, T W; Abbasi, A H

An extracorporeal regional complexing hemodialysis procedure is described which has been successfully applied for the enhancement of removal of methylmercury in the dog. The procedure utilizes the extracorporeal addition of cysteine to arterial blood entering a hemodialyzer, forming a large pool of complexed dialyzable methylmercury in plasma. Diffusion of this methylmercury complex across the dialyzer membrane into dialysate accounts for large amounts of methylmercury being removed from the animal. In conjunction with methylmercury removal, the majority of the infused cysteine is also removed resulting in comparatively low systemic doses of cysteine to the animal. At blood flow rates of 45 ml/min, and dialysate flow rates of approximately 550 ml/min, the mean percentage of methylmercury cleared from blood passing through the dialyzer was 39%. Rates of elimination of methylmercury from the dog could be increased by a factor of 100 during the extracorporeal regional complexing hemodialysis procedure. Regional collimated counting of radioactivity along the length of the dog revealed a decline in all areas including the head region. The procedure was void of any noticeable side effects during treatment or as evidence by histological evaluation of liver and kidney after treatment.

• Research Organization: Univ. of Rochester, NY
• OSTI ID: 6405084
• Journal Information: J. Pharmacol. Exp. Ther.; (United States), Journal Name: J. Pharmacol. Exp. Ther.; (United States) Vol. 203:2; ISSN JPETA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD FLOW
BODY FLUIDS
CARBOXYLIC ACIDS
CYSTEINE
DIALYSIS
DOGS
MAMMALS
METHYLMERCURY
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
ORGANIC SULFUR COMPOUNDS
POISONING
REMOVAL
SEPARATION PROCESSES
THIOLS
VERTEBRATES