Variability of gastric emptying time using standardized radiolabeled meals

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6403166

Christian, P E; Brophy, C M; Egger, M J; Taylor, A; Moore, J G

To define the range of inter- and intra-subject variability on gastric emptying measurements, eight healthy male subjects (ages 19-40) received meals on four separate occasions. The meal consisted of 150 g of beef stew labeled with Tc-99m SC labeled liver (600 ..mu..Ci) and 150 g of orange juice containing In-111 DTPA (100 ..mu..Ci) as the solid- and liquid-phase markers respectively. Images of the solid and liquid phases were obtained at 20 min intervals immediately after meal ingestion. The stomach region was selected from digital images and data were corrected for radionuclide interference, radioactive decay and the geometric mean of anterior and posterior counts. More absolute variability was seen with the solid than the liquid marker emptying for the group. The mean solid half-emptying time was 58 +- 17 min (range 29-92) while the mean liquid half-emptying time was 24 +- 8 min (range 12-37). A nested random effects analysis of variance showed moderate intra-subject variability for solid half-emptying times (rho = 0.4594), and high intra-subject variability was implied by a low correlation (rho = 0.2084) for liquid half-emptying. The average inter-subject differences were 58.3% of the total variance for solids (rho = 0.0017). For liquids, the inter-subject variability was 69.1% of the total variance, but was only suggestive of statistical significance (rho = 0.0666). The normal half emptying time for gastric emptying of liquids and solids is a variable phenomenon in healthy subjects and has great inter- and intra-individual day-to-day differences.

• Research Organization: Univ. of Utah School of Medicine, Salt Lake City, UT
• OSTI ID: 6403166
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL MARKERS
BODY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIET
DIGESTION
DIGESTIVE SYSTEM
DRUGS
DYNAMIC FUNCTION STUDIES
FOOD
GASTROINTESTINAL TRACT
IMAGES
LABELLED COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOPHARMACEUTICALS
SCINTISCANNING
STOMACH
VARIATIONS