Blood pressure and blood lead concentration in bus drivers

Journal Article · Wed Jun 01 00:00:00 EDT 1988 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.8878131· OSTI ID:6400929

Sharp, D S; Osterloh, J; Becker, C E; Bernard, B; Smith, A H; Fisher, J M; Syme, S L; Holman, B L; Johnston, T

San Francisco bus drivers have an increased prevalence of hypertension. This study examined relationships between blood lead concentration and blood pressure in 342 drivers. The analysis reported in this study was limited to subjects not on treatment for hypertension (n = 288). Systolic and diastolic pressure varied from 102 to 173 mm Hg and from 61 to 105 mm Hg, respectively. The blood lead concentration varied from 2 to 15 ..mu..g/dL. The relationship between blood pressure and the logarithm of blood lead concentration was examined using multiple regression analysis. Covariates included age, body mass index, sex, race, and caffeine intake. The largest regression coefficient relating systolic blood pressure and blood lead concentration was 1.8 mm Hg/ln (..mu..g/dL). The coefficient for diastolic blood pressure was 2.5 mm Hg/ln (..mu..g/dL). These findings suggest effects of lead exposure at lower blood lead concentrations than those concentrations that have previously been linked with increases in blood pressure.

• Research Organization: Univ. of California, Berkeley (USA)
• OSTI ID: 6400929
• Journal Information: Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 78; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL STRESS
BLOOD CHEMISTRY
BLOOD PRESSURE
CARDIOVASCULAR DISEASES
CHRONIC EXPOSURE
DISEASES
DOSE-RESPONSE RELATIONSHIPS
HUMAN POPULATIONS
HYPERTENSION
LEAD COMPOUNDS
PERSONNEL
POPULATIONS
SYMPTOMS
VASCULAR DISEASES