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Selective modification of the x ray survival response of two mouse mammary adenocarcinoma sublines by N,N-dimethylformamide

Journal Article · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
 [1]; ; ; ; ;
  1. Rhode Island Hospital, Providence
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The modification of the x ray survival response of two mammary adenocarcinoma tumor cell sublines by the polar solvent N,N-dimethylformamide (DMF) has been studied. The sublines (termed lines 66 and 67) differ significantly in their single dose survival responses to x-irradiation. Survival responses were fitted to the single-hit, multi-target, and linear-quadratic equations. For non-DMF treated cells, line 67 radiation parameters were: D/sub 0/(Gy) = 1.41, D/sub q/(Gy) = 1.41, n (extrapolation number) = 2.73. For line 66, these values were D/sub 0/ = 1.63, D/sub q/ = 3.01, n = 6.4. For investigation of DMF effects, cells were seeded at 1 x 10/sup 4/ per 25 cm/sup 2/ tissue culture flask in a DMF concentration of 0.8% (0.10 M) and allowed to multiply for 4 days. The survival parameters for line 67 (the radiosensitive line) then became D/sub 0/ = 1.56, D/sub q/ = 0.89, n = 1.77. For line 66 (the radioresistant line), the survival parameters were D/sub 0/ = 1.56, D/sub q/ = 0.94, n = 1.83. These results indins.

OSTI ID:
6394630
Journal Information:
Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 7:7; ISSN IOBPD
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDES
ANIMAL CELLS
ANIMALS
BODY
CELL KILLING
ELECTROMAGNETIC RADIATION
GLANDS
IN VITRO
IONIZING RADIATIONS
MAMMALS
MAMMARY GLANDS
MICE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RODENTS
SURVIVAL CURVES
TUMOR CELLS
VERTEBRATES
X RADIATION