Cardiac positron emission tomography

Journal Article · Sun Dec 01 04:00:00 EST 1985 · West. J. Med.; (United States)

OSTI ID:6389026

Geltman, E M

Positron emission tomography (PET) is a new technique for noninvasively assessing myocardial metabolism and perfusion. It has provided new insight into the dynamics of myocardial fatty acid and glucose metabolism in normal subjects, patients with ischemic heart disease and those with cardiomyopathies, documenting regionally depressed fatty acid metabolism during myocardial ischemia and infarction and spatial heterogeneity of fatty acid metabolism in patients with cardiomyopathy. Regional myocardial perfusion has been studied with PET using water, ammonia and rubidium labeled with positron emitters, permitting the noninvasive detection of hypoperfused zones at rest and during vasodilator stress. With these techniques the relationship between perfusion and the metabolism of a variety of substrates has been studied. The great strides that have been made in developing faster high-resolution instruments and producing new labeled intermediates indicate the promise of this technique for facilitating an increase in the understanding of regional metabolism and blood flow under normal and pathophysiologic conditions. 16 references, 9 figures, 2 tables.

• Research Organization: Washington Univ., School of Medicine, St. Louis, MO
• OSTI ID: 6389026
• Journal Information: West. J. Med.; (United States), Journal Name: West. J. Med.; (United States) Vol. 143:6; ISSN WJMDA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ALKALI METALS
AMMONIA
BIOLOGICAL FUNCTIONS
BLOOD FLOW
BODY
CARBOHYDRATES
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DATA
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELEMENTS
EMISSION COMPUTED TOMOGRAPHY
EXPERIMENTAL DATA
FUNCTIONS
GLUCOSE
HEART
HEXOSES
HYDRIDES
HYDROGEN COMPOUNDS
INFORMATION
METABOLISM
METALS
MONOSACCHARIDES
MUSCLES
MYOCARDIUM
NITROGEN COMPOUNDS
NITROGEN HYDRIDES
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
POSITRON COMPUTED TOMOGRAPHY
RUBIDIUM
SACCHARIDES
TOMOGRAPHY