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Performance of tapered column packed-bed bioreactor for ethanol production

Journal Article · · Biotechnol. Bioeng.; (United States)
A tapered column type of bioreactor system packed with immobilized Saccharomcyes cerevisiae was used to study the bioreactor performance as a function of design and operating variables. The performance of tapered column bioreactor system was found to be better than that of the conventional cylindrical column reactor system for the ethanol fermentation. The new bioreactor design alleviated problems associated with carbon dioxide evolution and provided a significantly better flow pattern for both liquid and gas phases in the bioreactor without local channelling. A mathematical simulation model, which takes into account the axial convection and dispersion, interphase mass transfer, and apparent kinetic design parameters, was developed. The effect of radial concentration gradients on the bioreactor performance was found to be insignificant. For the reactor system studied, the maximum ethanol productivity obtained was 60 g ethanol/L gel/h, and the maximum glucose assimilation rate was 140 g glucose/L gel/h. One of the most important findings from this study was the apparent kinetic parameters change at the glucose concentration of 2 g/L. This change was found to be due to the changes in yeast physiology and metabolism.
Research Organization:
Univ. of California, Davis
OSTI ID:
6386799
Journal Information:
Biotechnol. Bioeng.; (United States), Journal Name: Biotechnol. Bioeng.; (United States) Vol. 29:8; ISSN BIBIA
Country of Publication:
United States
Language:
English