EPA priorities for biologic markers research in environmental health
Technical Report
·
OSTI ID:6384576
Recent advances in molecular and cellular biology allow for measurement of biologic events or substances that may provide markers of exposure, effect or susceptibility in humans. The application of these new and emerging techniques to environmental health offers the possibility of significantly reducing the uncertainties that traditionally hamper risk assessments. The EPA health research program places a high priority on the validation of appropriate biologic markers and their application to high priority Agency issues. The rationale for EPA's biomarker research program is presented and future research directions are discussed. Exposure biomarkers will receive most of the research emphasis in the near term, particularly body burden indicators of exposures to high priority chemicals, such as benzene, ozone, selected heavy metals, and organophosphate pesticides. Research on effects biomarkers will attempt to validate the relationship between the observed biological effects and adverse health consequences in humans, especially for cancer, pulmonary toxicity, neurotoxicity, and reproductive/developmental toxicity.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (United States). Health Effects Research Lab.
- OSTI ID:
- 6384576
- Report Number(s):
- PB-93-181113/XAB; EPA--600/J-93/123
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AROMATICS
BENZENE
BIOLOGICAL EFFECTS
BIOLOGICAL MARKERS
BIOLOGY
BODY BURDEN
CHARGES
DATA PROCESSING
ELEMENTS
EPIDEMIOLOGY
HYDROCARBONS
INDICATORS
METALS
NATIONAL ORGANIZATIONS
ORGANIC COMPOUNDS
OZONE
PESTICIDES
POLLUTION
PROCESSING
PUBLIC HEALTH
RESEARCH PROGRAMS
RISK ASSESSMENT
TASK SCHEDULING
TESTING
TOXICITY
TRACE AMOUNTS
US EPA
US ORGANIZATIONS
VALIDATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AROMATICS
BENZENE
BIOLOGICAL EFFECTS
BIOLOGICAL MARKERS
BIOLOGY
BODY BURDEN
CHARGES
DATA PROCESSING
ELEMENTS
EPIDEMIOLOGY
HYDROCARBONS
INDICATORS
METALS
NATIONAL ORGANIZATIONS
ORGANIC COMPOUNDS
OZONE
PESTICIDES
POLLUTION
PROCESSING
PUBLIC HEALTH
RESEARCH PROGRAMS
RISK ASSESSMENT
TASK SCHEDULING
TESTING
TOXICITY
TRACE AMOUNTS
US EPA
US ORGANIZATIONS
VALIDATION