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The effect of cold storage of mitotic cells on hyperthermic killing and hyperthermic radiosensitization during G/sub 1/ and S

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3575929· OSTI ID:6380576
 [1]; ; ;
  1. AFRRI, Bethesda, MD
+ Show Author Affiliations
Mitotic cells were either plated directly into flasks in a 37/sup 0/C warm room or cooled and maintained at 1-2/sup 0/C for 3 hr prior to plating. The cold storage of mitotic cells delayed progression into the G/sub 1/ phase by 20-60 min and into S phase by 90-110 min. Cold storage also increased sensitivity to hyperthermic killing when the cells were heated during G/sub 1/ or S phase; i.e., a two- to threefold decrease in survival for 17 min of heating at 45.5/sup 0/C. However, cold storage did not increase hyperthermic radiosensitization during G/sub 1/.
OSTI ID:
6380576
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 92:3; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560201 -- Thermal Effects-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY TEMPERATURE
CELL CYCLE
CELL DIVISION
CELL KILLING
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
FIBROBLASTS
HAMSTERS
HYPERTHERMIA
IONIZING RADIATIONS
MAMMALS
MITOSIS
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
SURVIVAL CURVES
TEMPERATURE EFFECTS
VERTEBRATES
X RADIATION