Sister chromatid exchange, DNA repair, and single-gene mutation

Journal Article · Fri Jan 01 04:00:00 EST 1982 · UCLA Symp. Mol. Cell. Biol., New Ser.; (United States)

OSTI ID:6378885

Carrano, A V; Thompson, L H

Sister chromatid exchange (SCE) has been studied in cultured mammalian cells with regard to the nature of the inducing lesion, mutation induction, and factors that modify the observed frequency following mutagen exposure, SCEs can be induced by a wide spectrum of DNA lesions and, for nine agents examined, the frequency of induced SCE is linearly related to induced single-gene mutation. Further, a deficiency in DNA repair may alter the expression of both SCE and mutation in a qualitatively similar manner. The frequency of SCE induced by mitomycin-C is suppressed in heterochromatic relative to euchromatin and, in nondividing lymphocytes, the lesions leading to the formation of SCEs may persist for several months.

• Research Organization: Lawrence Livermore National Lab., CA
• DOE Contract Number: W-7405-ENG-48
• OSTI ID: 6378885
• Journal Information: UCLA Symp. Mol. Cell. Biol., New Ser.; (United States), Journal Name: UCLA Symp. Mol. Cell. Biol., New Ser.; (United States); ISSN USMBD
• Country of Publication: United States
• Language: English

Related Subjects

560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACRIDINES
ALKYLATING AGENTS
AMIDES
AMINES
ANIMAL CELLS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
AROMATICS
AZINES
BENZANTHRACENE
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CARBONIC ACID DERIVATIVES
CELL CULTURES
CHROMATIN
CHROMOSOMAL ABERRATIONS
CONDENSED AROMATICS
DATA
DNA
DRUGS
ELECTROMAGNETIC RADIATION
EMS
ESTERS
EXPERIMENTAL DATA
FLAVINES
GENE MUTATIONS
GENETIC EFFECTS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
INFORMATION
IONIZING RADIATIONS
MITOMYCIN
MUTAGENS
MUTANTS
MUTATIONS
NITROSO COMPOUNDS
NUCLEIC ACIDS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PROFLAVINE
PYRIDINES
RADIATIONS
RECOVERY
REPAIR
SISTER CHROMATID EXCHANGES
SULFONIC ACID ESTERS
ULTRAVIOLET RADIATION
UREA